Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulating<scp>AKT</scp>and<scp>CREB</scp>in rats

Ahmed, Ayaz; Zeng, Gaofeng; Azhar, Mudassar; Lin, Hua; Zhang, Mijia; Wang, Fengzhong; Zhang, Hong; Jiang, Dejian; Yang, Sijin; Farooq, Ahsana Dar; Choudhary, Muhammad Iqbal; Liu, Xinmin; Wang, Qiong

doi:10.1002/ptr.6773

Cited by 13 publications

(7 citation statements)

References 63 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ahmed et al (2020) during an investigation on diabetic rats with cognitive failures showed that this formula can improve learning and memory during MVM and NORT tests, also can reduce blood glucose levels and raise AKT and CREB protein expressions that are responsible for learning and memory in the brain tissue. It has been suggested that puerarin is the most effective component of this herbal mixture.…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Khazaei

Pesce

Patruno

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic defect with many complications for the patients. Deaths due to diabetes and its complications are increasing, and one of the most serious consequences are the neurological disorders. Chemical treatments have irreversible side effect and therefore the aim of this study is to evaluate the medicinal plants used for treatment of cognitive impairments and neurodegenerative diseases associated with diabetes in 2004–2020 period. Electronic databases used were PubMed, Scopus and Cochrane library. The keywords used were “diabetes,” “plant,” “herb,” “neurodegenerative,” “neurodegeneration,” “cognitive,” “cognition,” “Alzheimer,” “dementia.” The non‐English articles, repetitive articles and review studies were excluded. From total of 3,590 results, 58 articles are included in the study. The results show that many chemical treatments considered for this disease simply control hyperglycemia, but cannot improve the complications of diabetes. Herbal medicine could be more effective due to the high antioxidant activity of some medicinal plants. Biologically active substances of medicinal plants can improve the neurological disorders caused by diabetes via several pathways. The most important pathway is related to antioxidant properties. Other pathways include antiinflammatory, anti‐apoptotic, neurotoxicity inhibition, neuronal death, increasing the uptake of glucose by cells and improve neurotransmitters levels involved in learning and memory.

show abstract

Section: Resultsmentioning

confidence: 99%

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Khazaei

Pesce

Patruno

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…DCI is a neurodegenerative disease caused by diabetes and is characterized by dysfunction in cognitive functions such as verbal and visual memory, information processing speed, and executive function (Ahmed et al, 2020). Studies have revealed that diabetes increases the risk of cognitive impairment by a factor of 1.25–1.91 and that cognitive dysfunction in diabetes is present in all age groups, and hyperglycemia and hyperlipidemia are the key driving factors (Li et al, 2023; Nie et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF‐кB pathway through microbiota‐gut‐brain axis

Zhang

Deng

Chen

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being a crucial factor in its pathogenesis. Pterostilbene is a well‐known natural stilbene derivative that has excellent anti‐inflammatory activity, suggesting its potential medicinal advantages for treating DCI. Therefore, this study is to explore the beneficial effects of pterostilbene for improving cognitive dysfunction in DCI mice. A diabetic model was induced by a high‐fat diet plus streptozotocin (40 mg·kg−1) for consecutive 5 days. After the animals were confirmed to be in a diabetic state, they were treated with pterostilbene (20 or 60 mg·kg−1, i.g.) for 10 weeks. Pharmacological evaluation showed pterostilbene could ameliorate cognitive dysfunction, regulate glycolipid metabolism disorders, improve neuronal damage, and reduce the accumulation of β‐amyloid in DCI mice. Pterostilbene alleviated neuroinflammation by suppressing oxidative stress and carbonyl stress damage, astrocyte and microglia activation, and dopaminergic neuronal loss. Further investigations showed that pterostilbene reduced the level of lipopolysaccharide, modulated colon and brain TLR4/NF‐κB signaling pathways, and decreased the release of inflammatory factors, which in turn inhibited intestinal inflammation and neuroinflammation. Furthermore, pterostilbene could also improve the homeostasis of intestinal microbiota, increase the levels of short‐chain fatty acids and their receptors, and suppress the loss of intestinal tight junction proteins. In addition, the results of plasma non‐targeted metabolomics revealed that pterostilbene could modulate differential metabolites and metabolic pathways associated with inflammation, thereby suppressing systemic inflammation in DCI mice. Collectively, our study found for the first time that pterostilbene could alleviate diabetic cognitive dysfunction by inhibiting the TLR4/NF‐κB pathway through the microbiota‐gut‐brain axis, which may be one of the potential mechanisms for its neuroprotective effects.

show abstract

“…39,40 Thus, this study was designed to formulate R-SMS that comprises four bioactive components, namely Puerarin, Ginsenosides, Schizandrin, and Ruscogenin. 41 All the components of R-SMS have been shown to be neuroprotective, especially antidepressant activity among chronic unpredictable mild stress mouse models. [47][48][49][50] During diabetes various major end organs, including the brain, have exhibited enhanced inflammation and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, decoction for tonifying the kidney‐yin has shown to improve depression comorbidities in diabetes 39,40 . Recently, our group has shown that a combination of Shengmai San and Radix puerariae (R‐SMS) significantly improves learning and memory deficit in diabetic rats 41 . Therefore, this study was designed to explore the curative potential of R‐SMS to reverse diabetes‐associated depressive disorder in streptozotocin (STZ) rats and to elucidate its molecular mechanism at the nexus of PI3K/BDNF/SYN expression.…”

Section: Introductionmentioning

confidence: 99%

Combination of Shengmai San and Radix puerariae ameliorates depression‐like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression

Ahmed

Zeng

Azhar

et al. 2023

Anim Models and Exp Med

Self Cite

View full text Add to dashboard Cite

Background: Hyperglycemia is a characteristic feature of diabetes that often results in neuropsychological complications such as depression. Diabetic individuals are more vulnerable to experience depression compared to the normal population. Thus, novel treatment approaches are required to reduce depressive symptoms among diabetic individuals. Traditional Chinese medicines (TCMs) such as Shengmai San (SMS) and Radix puerariae (R) are usually widely used to treat ailments such as neurological complications since ancient time. Methods: In this study, SMS was combined with R to prepare an R-SMS formulation and screened for their antidepressant activity in diabetic rats. The antidepressant potential of the prepared combination was evaluated behaviorally using open field test, novelty-induced hypophagia, and forced swim test in diabetic rats with biochemical and protein expression (PI3K, BDNF [brain-derived neurotrophic factor], and SYN [presynaptic vesicle protein]) analysis. Results: Diabetic rats (streptozotocin, 45 mg/kg) showed elevated fasting blood glucose (FBG) >12 mM with depressive symptoms throughout the study. Treatment with R-SMS (0.5, 1.5, and 4.5 g/kg) significantly reverted depressive symptoms in diabetic rats as evinced by significantly (p < 0.05) reduced immobility time with an increased tendency to eat food in a novel environment. Treatment with R-SMS also significantly How to cite this article: Ahmed A, Zeng G, Azhar M, et al. Combination of Shengmai San and Radix puerariae ameliorates depression-like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression. Anim Models

show abstract

Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulatingAKTandCREBin rats

Cited by 13 publications

References 63 publications

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF‐кB pathway through microbiota‐gut‐brain axis

Combination of Shengmai San and Radix puerariae ameliorates depression‐like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression

Contact Info

Product

Resources

About