Jiawei Xianglian Decoction (JWXLD), a Traditional Chinese Medicine (TCM), Alleviates CPT‐11‐Induced Diarrhea in Mice

Lu, Jinhua; Lin, Zechen; Huang, Siyu; Shen, Yiwei; Jiang, Jing; Lin, Shengyou

doi:10.1155/2020/7901231

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…Pro-inflammatory cytokines such as IL-6 and TNF-α are associated with tissue damage ( Hernández-Rodríguez et al., 2004 ). Evidence suggests that the inhibition of pro-inflammatory cytokines (IL-1, IL-6, and TNF-α) supports the protective effect of Jiawei Xianglian Decoction on diarrhea induced by irinotecan ( Lu et al., 2020 ). In the diarrhea piglets model induced by E. coli , the results showed that L. plantarum ZLP001 could significantly inhibit the increase of intestinal permeability induced by E. coli , reduce the expression levels of IL-6 , IL-8 , and TNF-α , and prevent the increase of tight-junction protein expression ( Wang et al., 2018 ).…”

Section: Probiotics and Intestinal Diseases Of Monogastric Animalsmentioning

confidence: 94%

The impact of probiotics on gut health via alternation of immune status of monogastric animals

Ding

Yan

et al. 2021

Animal Nutrition

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The intestinal immune system is affected by various factors during its development, such as maternal antibodies, host genes, intestinal microbial composition and activity, and various stresses (such as weaning stress). Intestinal microbes may have an important impact on the development of the host immune system. Appropriate interventions such as probiotics may have a positive effect on intestinal immunity by regulating the composition and activity of intestinal microbes. Moreover, probiotics participate in the regulation of host health in many ways; for instance, by improving digestion and the absorption of nutrients, immune response, increasing the content of intestinal-beneficial microorganisms, and inhibiting intestinal-pathogenic bacteria, and they participate in regulating intestinal diseases in various ways. Probiotics are widely used as additives in livestock and the poultry industry and bring health benefits to hosts by improving intestinal microbes and growth performance, which provides more choices for promoting strong and efficient productivity.

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Section: Probiotics and Intestinal Diseases Of Monogastric Animalsmentioning

confidence: 94%

The impact of probiotics on gut health via alternation of immune status of monogastric animals

Ding

Yan

et al. 2021

Animal Nutrition

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“…CPT‐11 is widely used in malignant chemotherapy, but delayed diarrhea, one of its dose‐limiting toxic reactions, causes patients unable to tolerate treatment of CPT‐11 and seriously affects the course of chemotherapy (Bailly, 2019; Kweekel et al, 2008). The clinical application of traditional Chinese medicine (TCM) to prevent and treat CPT‐11‐triggered delayed diarrhea is of great importance (Lu et al, 2020; Wang et al, 2011; Yue et al, 2021). Therefore, the mechanism of the prevention and treatment of CPT‐11‐caused late‐onset diarrhea using TCM required more rigorous and reliable researches, and the relevant target genes and target proteins need to be unveiled.…”

Section: Discussionmentioning

confidence: 99%

Baicalein, a component of banxia xiexin decoction, alleviates CPT‐11‐induced gastrointestinal dysfunction by inhibiting ALOX15‐mediated ferroptosis

Pei,

Zou,

Zhou

et al. 2023

Chem Biol Drug Des

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Baicalein, one of the active ingredients of banxia xiexin decoction, has good therapeutic efficacy in treating diarrhea and improving gastrointestinal dysfunction. The role and mechanism of Baicalein on irinotecan (CPT‐11)‐induced gastrointestinal dysfunction are the focus of this study. Concretely, CPT‐11 induced delayed diarrhea rat model and intestinal epithelial cell (IEC)‐6 cell injury model with Baicalein treatment as needed. Colonic pathological changes were analyzed by hematoxylin–eosin staining, and inflammatory factor expressions in serum were determined by enzyme‐linked immunosorbent assay. Immunohistochemistry and western blot were performed to quantify ferroptosis‐related protein expressions. Thiobarbituric acid reactive substances (TBARS) kits and colorimetric assay kit were applied to detect lipid peroxidation levels and Fe2+ content, respectively. In vitro experiments also included quantitative real‐time polymerase chain reaction, cell counting kit‐8, and C11 BODIPY staining. CPT‐11 induced aggravation of intestinal tissue damage, inflammatory factor release, Fe2+ accumulation, upregulation of lipid peroxidation and 15‐Lipoxygenase (ALOX15) expression, and downregulation of glutathione peroxidase 4 (Gpx4) and SLC7A11 in vivo in rats; however, Baicalein dose‐dependently reversed the effects of CPT‐11. Baicalein elevated cell viability, reduced lipid peroxidation and Fe2+ accumulation, and elevated Gpx4 and SLC7A11 levels, whereas ALOX15 overexpression reversed the effects of Baicalein on a CPT‐11‐induced IEC‐6 cell injury model. In conclusion, Baicalein plays a mitigating role in CPT‐11‐induced delayed diarrhea via ALOX15‐mediated ferroptosis.

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“…Also, it can effectively inhibit CPT-11-induced multiplication and differentiation of multiple inflammatory markers and alleviate CPT-11 chemotherapy-induced diarrhea ( 12 ). In addition, some monomers and active ingredients in SBWGR, such as Muxiang and hesperidin, have also been shown to reduce the expressions of some inflammatory factors (e.g., TNF-α) and inhibit the apoptosis of intestinal epithelial cells, thus alleviating the toxic damage of CPT-11 to the intestinal tract ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Shu Bu Wenshen Guchang recipe on intestinal injury and the TLR4/NF-κB signaling pathways in mice with irinotecan-induced delayed-type diarrhea

Zhang¹,

Jiang²,

Jin³

et al. 2022

Transl Cancer Res TCR

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Background: Irinotecan (also known as ) is a topoisomerase I inhibitor that is primarily used for the treatment of advanced colorectal cancer. CPT-11 and its active metabolite SN-38 can directly damage intestinal mucosal cells. In addition, CPT-11 can activate the Toll-like receptor 4 (TLR4) inflammasome/ nuclear factor kappa-B p65 (NF-κB p65) pathway, ultimately leading to intestinal inflammation-related injury. Shu Bu Wenshen Guchang recipe (SBWGR) has the spleen and kidneys. Herein, we investigated the effects of SBWGR on intestinal injury and the TLR4/NF-κB signaling pathways in mice with CPT-11induced delayed-type diarrhea, aiming to provide evidence for the treatment of CPT-11-induced delayedtype diarrhea.Methods: Thirty tumor-bearing mice were divided into normal control, model control, octreotide, low dose SBWGR, and high dose SBWGR groups, with 6 mice in each group. After successful modelling of delayed diarrhea, the normal and model control groups were given equal amounts of saline for 5 consecutive days, and the other three groups gave the corresponding intra-drug administration. Body weight, tumor size, Chiu score, intestinal ischemia and reperfusion injury, and disease activity index (DAI) were recorded in each group. The levels of intestinal interleukin-1β (IL-1β), IL-18, and tumor necrosis factor-α (TNF-α) were measured by an enzyme-linked immunosorbent assay (ELISA). Intestinal TLR4 and NF-κB p65 levels were measured by reverse transcription-polymerase chain reaction (RT-PCR) and protein blotting. Results:The weight of octreotide and kidney was higher than the control group (P<0.05); The tumor volume comparison of the model control group, octreotide group, warm kidney intestine low dose group, and warm kidney intestine high dose group were not significantly different (P>0.05). Octreotide group, intestinal Chiu score, diarrhea score, DAI level, intestinal inflammatory cytokines, IL-1β, IL-18 and TNF-α intestinal level, intestinal TLR4, NF-κB p65 mRNA protein expression levels were significantly lower than those of the model control group (P<0.05), and the amount of the treatment group was increased (P<0.05).Conclusions: SBWGR exerts a prominent protective effect on intestinal damage caused by CPT-11induced delayed-type diarrhea, which may be achieved by inhibiting the activation of the intestinal TLR4/ NF-κB signaling pathway.

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Jiawei Xianglian Decoction (JWXLD), a Traditional Chinese Medicine (TCM), Alleviates CPT‐11‐Induced Diarrhea in Mice

Cited by 9 publications

References 40 publications

The impact of probiotics on gut health via alternation of immune status of monogastric animals

The impact of probiotics on gut health via alternation of immune status of monogastric animals

Baicalein, a component of banxia xiexin decoction, alleviates CPT‐11‐induced gastrointestinal dysfunction by inhibiting ALOX15‐mediated ferroptosis

Effects of Shu Bu Wenshen Guchang recipe on intestinal injury and the TLR4/NF-κB signaling pathways in mice with irinotecan-induced delayed-type diarrhea

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