Jinggangmycin increases fecundity of the brown planthopper, Nilaparvata lugens (Stål) via fatty acid synthase gene expression

Li, Lei; Jiang, Yiping; Liu, Zongyu; You, Linlin; Wu, You; Xu, Bing; Ge, Lin-Quan; Stanley, David; Song, Qisheng; Wu, Jin-Cai

doi:10.1016/j.jprot.2015.09.022

Cited by 42 publications

(40 citation statements)

References 31 publications

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“…JGM treatments also led to increased fecundity, as we recently reported2021. Taken with the data reported here, these papers provide new insights into the influence of agricultural chemicals on BPH biology.…”

Section: Discussionsupporting

confidence: 88%

“…The influence of JGM on BPH fecundity appears to act through several enzymes. Acetyl-CoA carboxylase (Acc)20 and fatty acid synthase (FAS)21 act in fatty acid synthesis and separately silencing genes encoding these enzymes eliminates the JGM-enhanced BPH fecundity. This work helps to understand the adaptive mechanisms planthoppers have evolved that lead to chemically-induced enhancements inBPH fecundity.…”

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confidence: 99%

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Driving Pest Insect Populations: Agricultural Chemicals Lead to an Adaptive Syndrome in Nilaparvata Lugens Stål (Hemiptera: Delphacidae)

You

et al. 2016

Sci Rep

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The brown planthopper (BPH) is a devastating pest of rice throughout Asia. In this paper we document the BPH biogeographic range expansion in China over the 20-year period, 1992 to 2012. We posed the hypothesis that the range expansion is due to a syndrome of adaptations to the continuous presence of agricultural chemicals (insecticides and a fungicide) over the last 40 years. With respect to biogeography, BPH ranges have expanded by 13% from 1992 to 1997 and by another 3% from 1997 to 2012. In our view, such expansions may follow primarily from the enhancing effects of JGM, among other agricultural chemicals, and from global warming. JGM treatments led to increased thermotolerance, recorded as decreased mortality under heat stress at 40 ± 1 °C (down from 80% to 55%) and increased fecundity (by 49%) at 34 °C. At the molecular level, JGM treatments led to increased abundances of mRNA encoding Acetyl Co-A carboxylase (Acc) (up 25%) and Hsp70 (up 32%) in experimental BPH. RNAi silencing of Hsp70 and Acc eliminated the JGM effects on fecundity and silencing Hsp70 reduced JGM-induced thermotolerance. Integrated with global climate change scenarios, such syndromes in pest insect species have potential for regional- and global-scale agricultural disasters.

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Section: Discussionsupporting

confidence: 88%

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confidence: 99%

Driving Pest Insect Populations: Agricultural Chemicals Lead to an Adaptive Syndrome in Nilaparvata Lugens Stål (Hemiptera: Delphacidae)

You

et al. 2016

Sci Rep

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“…As reproduction was energetically linked through lipid metabolism, therefore, the decreased activities of ACACA and FASN could reduce lipid biosynthesis to have influences on fecundity . Based on our results, we suggested that azadirachtin treatment caused infertility via suppression lipid biosynthesis, interfering meiotic arrest, and impairing sex chromosomes during development of testis at adult stage …”

Section: Discussionmentioning

confidence: 68%

Proteomic Profiling Analysis of Male Infertility inSpodoptera LituraLarvae Challenged with Azadirachtin and its Potential‐Regulated Pathways in the Following Stages

et al. 2018

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Biopesticides are considered as an alternative to synthetic pesticide with a focus on increasing agricultural productivity as well as maintaining the ecosystem. Prior to application, its potential mechanism should be clearly addressed. Here, the effects of azadirachtin on the reproductive behavior in male Spodoptera litura (Fabricius) are determined. To further explore its molecular mechanism, an iTRAQ (isobaric tags for relative and absolute quantitation) based approach is applied to identify the differentially expressed proteins regulated by azadirachtin at two developmental stages. The results demonstrate that many proteins in the pathway of focal adhesion are regulated to exert influences in detachment of cell attachment, the loss of cell-cell interactions and inducing apoptosis at pupal stage, and many proteins in adenosine monophosphate-activated protein kinase pathway are also changed at the adult stage after azadirachtin-treatment as larvae. Moreover, based on their important roles, it is suggested that some proteins, such as ACTB-G1, ste20-related adaptor protein alpha, and regulatory-associated protein of mTOR (mTORC1) could serve as potential target proteins of azadirachtin to induce male infertility. The results of this study could provide evidence to illuminate the mechanism of male infertility induced by azadirachtin and potential targets for the development of environmentally friendly pesticides.

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“…The influence of these chemicals operates through multiple systems, including carbohydrate transport19, protein biosynthesis18, developmental hormones18 and lipid biosynthesis20. Treating males with either of the insecticides, the organophosphate tzp or the pyrethroid, deltamethrin, led to increased protein contents in treated males and in untreated females after mating with treated males3.…”

Section: Discussionmentioning

confidence: 99%

Suppressing male spermatogenesis-associated protein 5-like gene expression reduces vitellogenin gene expression and fecundity in Nilaparvata lugens Stål

Xia

Huang

et al. 2016

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In our previous study with the brown planthopper (BPH), Nilaparvata lugens, triazophos (tzp) treatments led to substantial up-regulation of a male spermatogenesis-associated protein 5-like gene (NlSPATA5) compared to untreated controls. Mating with tzp-treated males significantly increased fecundity (as numbers of eggs laid), relative to females mated with untreated males. Because SPATA5 acts in mammalian sperm development and is expressed in testes, we posed the hypothesis that NlSPATA5 occurs in BPH seminal fluid and it operates in fecundity via mating. We tested the hypothesis by investigating the influence of suppressing NlSPATA5 expression in BPH males on fecundity. Reduced expression of NlSPATA5 led to decreased male accessory gland protein content and reproductive system development compared to controls. These changes in males led to prolonged pre-oviposition periods and decreased fecundity in females. For both genders, we recorded no difference in the body weight, oviposition periods, and longevity compared to controls. NlSPATA5 suppression in males also led to decreased fat body and ovarian protein content, yeast-like symbionts abundance and ovarian development as well as vitellogenin gene expression in their mating partners. We infer that increased NlSPATA5 expression may be one molecular mechanism of tzp-driven reproduction and population increases in BPH.

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Jinggangmycin increases fecundity of the brown planthopper, Nilaparvata lugens (Stål) via fatty acid synthase gene expression

Cited by 42 publications

References 31 publications

Driving Pest Insect Populations: Agricultural Chemicals Lead to an Adaptive Syndrome in Nilaparvata Lugens Stål (Hemiptera: Delphacidae)

Driving Pest Insect Populations: Agricultural Chemicals Lead to an Adaptive Syndrome in Nilaparvata Lugens Stål (Hemiptera: Delphacidae)

Proteomic Profiling Analysis of Male Infertility inSpodoptera LituraLarvae Challenged with Azadirachtin and its Potential‐Regulated Pathways in the Following Stages

Suppressing male spermatogenesis-associated protein 5-like gene expression reduces vitellogenin gene expression and fecundity in Nilaparvata lugens Stål

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