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Five-membered oxaza heterocyclic compounds on the basis of epoxides and aziridines

“…Ammazzalorso et al [77] described preliminary structural modification of both initial reactants (epoxide and amine) in the synthesis of compound 29 (Scheme 15). These data are consistent with the results of other studies [72,78,79] on the synthesis of oxazolidin-2-ones 30 via reactions of aryl glycidyl ethers 31 and their analogs (Scheme 16). Epoxide 32 was used as starting compound to obtain potent (+)-L-733 060 neurokinin-1 receptor antagonist [80] (Scheme 17).…”

Synthesis of New Aromatic Isatin Derivatives

“…1 The IR spectra were recorded on a Specord 75IR spectrometer from samples dispersed in mineral oil. A solution of 1 g (4.9 mmol) of bis(chloromethyl)dimethylbenzene IIIV in 10 ml of anhydrous DMF was added dropwise under stirring to a solution of 1.66 g (9.8 mmol) isatin sodium salt II in 10 ml of anhydrous DMF.…”

New isatin derivatives

“…A synthesis is described of 5,5-dimethylhydantoin-3-N-ethylisatin from the isatin sodium salt and 5,5-dimethyl-3-N-(2-chloroethyl)hydantoin [59]. Various methods of introducing lactam ring into the structure of organic compounds were investigated [60,61].…”

“…Also derivatives of N-phenylanthranilic acid are of interest that has previously underlain the production of acridone, acrichine, rivanol yellow [62,63] The reaction of sodium isatin with 1,4-bis-(chloromethyl)benzene was investigated; at heating in benzene at the molar ratio 2:1 formed 1,4-bis-(isatinomethyl)benzene, and in DMF at the room temperature a mixture of mono-and disubstituted products was obtained. The reaction of isatin sodium salt with 2,5-bis-(chloromethyl)-p-xylene in a ratio 2:1 in DMF at the room temperature furnished in 2 days 2,5-bis(1-isatinomethyl)-p-xylene and 2-(isatinomethyl)-5-(chloromethyl)-pxylene [64].…”