JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy

Tan, Juan; Wang, Hao-Lian; Yang, Jie; Liu, Qianqian; Li, Chunmin; Wang, Yun-Qian; Fu, Liang; Gao, Qin-Yan; Chen, Yingxuan; Fang, Jing‐Yuan

doi:10.7150/thno.38087

Cited by 18 publications

(15 citation statements)

References 55 publications

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“…by inhibiting autophagy (33). We also found that the expression of all four genes were higher in tumor tissues than in normal tissues by RT-PCR.…”

Section: Discussionsupporting

confidence: 52%

“…To compare differences in immune cell infiltration in the high-and low-risk groups in the HNSCC samples, the CIBERSORT algorithm was used to calculate the abundance of 22 types of immune cells, including subpopulations of T cells (32). The enrichment scores were calculated using the singlesample gene set enrichment analysis algorithm (ssGSEA) using the package R "GSVA" (version 1.444.0) to indicate the relative extent of expression of each immune-related feature in each sample, and to compare the difference in enrichment scores between the low-and high-risk groups (33). The immune checkpoints (ICs) were derived from the literature.…”

Section: Immunity and Tumor Microenvironmentmentioning

confidence: 99%

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A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas

Zou²,

An³

et al. 2022

Front. Oncol.

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We investigated the role of amino acid metabolism (AAM) in head and neck squamous cell carcinoma (HNSCC) tissues to explore its prognostic value and potential therapeutic strategies. A risk score based on four AAM-related genes (AMG) was constructed that could predict the prognosis of HNSCC. These four genes were up-regulated in HNSCC tissues and might act as oncogenes. Internal validation in The Cancer Genome Atlas (TCGA) by bootstrapping showed that patients with high-risk scores had a poorer prognosis than patients with low-risk scores, and this was confirmed in the Gene Expression Omnibus (GEO) cohort. There were also differences between the high-risk and low-risk groups in clinical information and different anatomical sites such as age, sex, TNM stage, grade stage, surgery or no surgery, chemotherapy, radiotherapy, no radiotherapy, neck lymph node dissection or not, and neck lymphovascular invasion, larynx, overlapping lesion of lip, and oral cavity and pharynx tonsil of overall survival (OS). Immune-related characteristics, tumor microenvironment (TME) characteristics, and immunotherapy response were significantly different between high- and low-risk groups. The four AMGs were also found to be associated with the expression of markers of various immune cell subpopulations. Therefore, our comprehensive approach revealed the characterization of AAM in HNSCC to predict prognosis and guide clinical therapy.

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“…by inhibiting autophagy (33). We also found that the expression of all four genes were higher in tumor tissues than in normal tissues by RT-PCR.…”

Section: Discussionsupporting

confidence: 52%

Section: Immunity and Tumor Microenvironmentmentioning

confidence: 99%

A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas

Zou²,

An³

et al. 2022

Front. Oncol.

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“…The depletion of oxygen triggers the glycolysis process in the tumor cells to gain energy in an efficient manner, which further accelerates the deprivation of glucose in tumor. Suppressing the supply of glucose and/or oxygen can inhibit the growth of tumor cells, thus achieving effective starvation therapy 9 - 11 . Despite tremendous efforts toward tumor therapy, mono-modality therapy often does not provide satisfactory therapeutic effect in managing cancer patients due to the high heterogeneity and pathological complexity of tumors.…”

Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

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Rationale: Nanoscale vehicles responsive to abnormal variation in tumor environment are promising for use in targeted delivery of therapeutic drugs specifically to tumor sites. Herein, we report the design and fabrication of self-accelerating H 2 O 2 -responsive plasmonic gold nanovesicles (GVs) encapsulated with tirapazamine (TPZ) and glucose oxidase (GOx) for synergistic chemo/starving therapy of cancers. Methods: Gold nanoparticles were modified with H 2 O 2 -responsive amphiphilic block copolymer PEG 45 - b -PABE 330 by ligand exchange. The TPZ and GOx loaded GVs (TG-GVs) were prepared through the self-assembly of PEG 45 - b -PABE 330 -grafted nanoparticles together with TPZ and GOx by solvent displacement method. Results: In response to H 2 O 2 in tumor, the TG-GVs dissociate to release the payloads that are, otherwise, retained inside the vesicles for days without noticeable leakage. The released GOx enzymes catalyze the oxidation of glucose by oxygen in the tumor tissue to enhance the degree of hypoxia that subsequently triggers the reduction of hypoxia-activated pro-drug TPZ into highly toxic free radicals. The H 2 O 2 generated in the GOx-catalyzed reaction also accelerate the dissociation of vesicles and hence the release rate of the cargoes in tumors. The drug-loaded GVs exhibit superior tumor inhibition efficacy in 4T1 tumor-bearing mice owing to the synergistic effect of chemo/starvation therapy, in addition to their use as contrast agents for computed tomography imaging of tumors. Conclusion: This nanoplatform may find application in managing tumors deeply trapped in viscera or other important tissues that are not compatible with external stimulus (e.g. light).

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“… 84 Additionally, under glucose deficient conditions, JMJD2B sustained the autophagy-derived amino acids in CRC cells via the epigenetic regulation of LC3B, thereby promoting the aggressiveness of CRC. 85 Similar to its action mechanism in gastric cancer, JMJD2B supports the gene transcription induced by β-catenin, thereby contributing to the tumorigenesis of CRCs. 86 The invasion of CRC cells may also be attributed to the immune escape via the KDM4B/HOXC4/PD-L1 axis.…”

Section: Jmjd Proteins In Cancermentioning

confidence: 99%

JMJD family proteins in cancer and inflammation

Wang

Xue

Hong

et al. 2022

Sig Transduct Target Ther

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The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis. Epigenetic changes such as the dysregulation of enzymes modifying DNA or histones are actively involved in oncogenesis and inflammatory response. The methylation of lysine residues on histone proteins represents a class of post-translational modifications. The human Jumonji C domain-containing (JMJD) protein family consists of more than 30 members. The JMJD proteins have long been identified with histone lysine demethylases (KDM) and histone arginine demethylases activities and thus could function as epigenetic modulators in physiological processes and diseases. Importantly, growing evidence has demonstrated the aberrant expression of JMJD proteins in cancer and inflammatory diseases, which might serve as an underlying mechanism for the initiation and progression of such diseases. Here, we discuss the role of key JMJD proteins in cancer and inflammation, including the intensively studied histone lysine demethylases, as well as the understudied group of JMJD members. In particular, we focused on epigenetic changes induced by each JMJD member and summarized recent research progress evaluating their therapeutic potential for the treatment of cancer and inflammatory diseases.

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JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy

Cited by 18 publications

References 55 publications

A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas

A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

JMJD family proteins in cancer and inflammation

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JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy

Cited by 18 publications

References 55 publications

A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas

A multifaceted and feasible prognostic model of amino acid metabolism-related genes in the immune response and tumor microenvironment of head and neck squamous cell carcinomas

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

JMJD family proteins in cancer and inflammation

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Product

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Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors