JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis

Ki, Yeo-Woon; Park, Jae Hyeon; Lee, Jeong Eun; Shin, In Chul; Koh, Hyun Chul

doi:10.1016/j.toxlet.2013.02.003

Cited by 171 publications

(97 citation statements)

References 56 publications

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“…A previous study demonstrated that various stress stimuli, including the oxidative stress caused by ROS, may induce potential activation of MAPK signaling pathways (24). In addition, the activation of JNK contributes to stress-induced apoptosis (25). p38 MAPK has been demonstrated to either promote apoptosis or enhance cell survival depending on the cell type and stimulus (26,27).…”

Section: Discussionmentioning

confidence: 99%

Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

et al. 2016

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Abstract. Phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) signaling cascades have significant roles in cell proliferation, survival, angiogenesis and metastasis of tumor cells. Eupatilin, one of the major compounds present in Artemisia species, has been demonstrated to have antitumor properties. However, the effect of eupatilin in renal cell carcinoma (RCC) remains to be elucidated. Therefore, the present study investigated the biological effects and mechanisms of eupatilin in RCC cell apoptosis. The results of the present study demonstrated that eupatilin significantly induced cell apoptosis and enhanced the production of reactive oxygen species (ROS) in 786-O cells. In addition, eupatilin induced phosphorylation of p38α (Thr180/Tyr182), extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase 1/2 (Thr183/Tyr185), and decreased the phosphorylation of PI3K and AKT in 786-O cells in a concentration-dependent manner. Furthermore, the ROS inhibitor N-acetyl-L-cysteine was able to rescue the MAPK activation and PI3K/AKT inhibition induced by eupatilin. Taken together, the results of the present study provide evidence that inhibition of eupatilin induces apoptosis in human RCC via ROS-mediated activation of the MAPK signaling pathway and inhibition of the PI3K/AKT signaling pathway. Thus, eupatilin may serve as a potential therapeutic agent for the treatment of human RCC.

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Section: Discussionmentioning

confidence: 99%

Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

et al. 2016

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“…COX-2 drives the inflammatory response and is implicated in some mechanisms of cell death. 35 Amfenac amide is a prodrug that is converted to amfenac by intraocular hydrolases. Amfenac inhibits both cyclooxygenase COX-1 and COX-2 activity.…”

Section: Discussionmentioning

confidence: 99%

Melatonin and amfenac modulate calcium entry, apoptosis, and oxidative stress in ARPE-19 cell culture exposed to blue light irradiation (405 nm)

Argun

Tök

Uğuz

et al. 2014

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“…Zhou et al [16] showed that the disruption of intestinal epithelial cell was closely related to apoptosis and oxidative damage in rats. Studies revealed that the gene expression of TJs, apoptosis and antioxidant capacity could be regulated by myosin light chain kinase (MLCK) [17], c-Jun N-terminal protein kinase (JNK) [18] and NF-E2-related factor 2 (Nrf2) [19] in humans, respectively. However, no study has addressed the effects of dietary proteins on the intestinal physical barriers and its possible mechanism in fish.…”

Section: Introductionmentioning

confidence: 99%

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Jiang

et al. 2016

Fish & Shellfish Immunology

123

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JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis

Cited by 171 publications

References 56 publications

Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

Melatonin and amfenac modulate calcium entry, apoptosis, and oxidative stress in ARPE-19 cell culture exposed to blue light irradiation (405 nm)

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

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