2004
DOI: 10.1038/sj.bjc.6601834
|View full text |Cite
|
Sign up to set email alerts
|

JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA)

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

3
12
0

Year Published

2005
2005
2017
2017

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 26 publications
(15 citation statements)
references
References 30 publications
3
12
0
Order By: Relevance
“…Using pharmacological inhibitors of JNK and p38 MAPK we determined that these two pathways are not involved in the release of apoptotic factors but instead they are effectors of the autocrine factors in prostate cancer cells. Previous studies have determined that p38 MAPK and JNK become activated by phorbol ester treatment in LNCaP prostate cancer cells (9,13,26), and that p38 MAPK inhibitors interfere with PMA-induced apoptosis in these cells (9), which support our experimental conclusions.…”
Section: Tnf␣ Is Required For Pma-induced Apoptosis In Lncap Prostatesupporting
confidence: 81%
See 2 more Smart Citations
“…Using pharmacological inhibitors of JNK and p38 MAPK we determined that these two pathways are not involved in the release of apoptotic factors but instead they are effectors of the autocrine factors in prostate cancer cells. Previous studies have determined that p38 MAPK and JNK become activated by phorbol ester treatment in LNCaP prostate cancer cells (9,13,26), and that p38 MAPK inhibitors interfere with PMA-induced apoptosis in these cells (9), which support our experimental conclusions.…”
Section: Tnf␣ Is Required For Pma-induced Apoptosis In Lncap Prostatesupporting
confidence: 81%
“…TNF␣ and TRAIL receptors activate various signaling cascades, including the JNK, p38 MAPK, and NF-B pathways. Whereas NF-B mediates mainly anti-apoptotic signals in prostate cancer cells, including LNCaP cells (23,24), emerging evidence suggests a prominent pro-apoptotic role for p38 MAPK and JNK in prostate cancer cells (9,13,25,26). We found that CM-PMA significantly activates JNK and p38 MAPK in LNCaP cells, as revealed by Western blot using phospho-specific JNK and p38 MAPK antibodies.…”
Section: Involvement Of the Extrinsic Apoptotic Pathway In The Pkc-mementioning
confidence: 65%
See 1 more Smart Citation
“…Previous studies have determined that JNK can be activated following phorbol ester treatment in LNCaP cells (7,26). In the current study, KLF5 was detected to regulate phosphorylation of JNKs.…”
Section: Discussionmentioning
confidence: 99%
“…For example, 12-O-tetradecanoyl phorbol 13-acetate-induced phosphorylation of JNK, resulting in apoptosis of androgen-dependent human prostate cancer cells. 21 On the other hand, activation of JNK was required for interleukin-3-dependent proliferation of Ba/F3 murine pre-B cells. 22 In addition, JNK was shown to be required for survival and proliferation of B-lymphoma cells.…”
mentioning
confidence: 99%