Job and Industry Classifications Associated With Sarcoidosis in a Case–Control Etiologic Study of Sarcoidosis (ACCESS)

Barnard, Juliana; Rose, Cecile S.; Newman, Lee S.; Canner, Martha; Martyny, John W.; McCammon, Chuck; Bresnitz, Eddy A.; Rossman, M. D.; Thompson, Bruce; Rybicki, Benjamin A.; Weinberger, Steven E.; Möller, David R.; McLennan, Geoffrey; Hunninghake, Gary W.; DePalo, Louis; Baughman, Robert P.; Iannuzzi, Michael C.; Judson, Marc A.; Knatterud, Genell L.; Teirstein, Alvin S.; Yeager, Henry; Johns, Carol J.; Rabin, David L.; Cherniack, Reuben M.

doi:10.1097/01.jom.0000155711.88781.91

Cited by 112 publications

(80 citation statements)

References 15 publications

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“…Exposure to bio-aerosols, as well as mold/mildew exposures and contact with insecticides, were described to be associated with a higher sarcoidosis frequency by the ACCESS (A Case-Control Etiologic Study of Sarcoidosis) study [3]. Along these lines, exposure to high humidity, mold/mildew, water damage or musty odour were associated with a higher frequency of sarcoidosis in African-American siblings [4].…”

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confidence: 68%

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Prevalence of sarcoidosis in Switzerland is associated with environmental factors

Deubelbeiss¹,

Gemperli²,

Schindler³

et al. 2009

Eur Respir J

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The current study aimed to investigate incidence, prevalence and regional distribution of sarcoidosis in Switzerland with respect to environmental exposures.All sarcoidosis patients hospitalised between 2002 and 2005 were identified from the Swiss hospital statistics from the Swiss Federal Office for Statistics (Neuchâtel, Switzerland). Regional exposure characteristics included the regional distribution of different industrial sectors, agriculture and air quality. Co-inertia analysis, as well as a generalised linear model, was applied.The prevalence of ''ever-in-life'' diagnosed sarcoidosis, currently active sarcoidosis and sarcoidosis requiring hospitalisation was 121 (95% CI 93-149), 44 (95% CI 34-54) and 16 (95% CI 10-22) per 100,000 inhabitants, respectively. The mean annual incidence of sarcoidosis was 7 (95% CI 5-11) per 100,000 inhabitants. The regional workforce in the metal industry, water supply, air transport factories and the area of potato production, artificial meadows (grassland) and bread grains were positively associated with the frequency of sarcoidosis.The prevalence of sarcoidosis was higher than assumed based on former international estimates. Higher frequency was found in regions with metal industry and intense agriculture, especially production of potatoes, bread grains and artificial meadows.

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confidence: 68%

“…Other studies have sought associations with specific jobs and workplaces within the metal industry [3,5,37]. Exposure to a metalworking plant, either by vicinity of residence or professional exposure, could represent a risk factor for the development of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sarcoidosis in Switzerland is associated with environmental factors

Deubelbeiss¹,

Gemperli²,

Schindler³

et al. 2009

Eur Respir J

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“…There is a significant association between an increased risk of IPF and exposure to cigarette smoking, metal and wood dust, stone sand, and farming and livestock [11][12][13][14][15][16], and people employed in agriculture or by suppliers of hardware and building and gardening materials, or exposed to wood or organic dust, are at increased risk for sarcoidosis. Metal dusts and fumes, musty odors, microbial-rich environments and smoking are either occupational or environmental risk factors for sarcoidosis [10,17,18].…”

Section: Introductionmentioning

confidence: 99%

Metallic elements in exhaled breath condensate of patients with interstitial lung diseases

Corradi¹,

Acampa²,

Goldoni³

et al. 2009

J. Breath Res.

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Epidemiological data support the hypothesis that environmental and occupational agents play an important role in the development of interstitial lung diseases such as idiopathic interstitial pneumonia (IIPs) and sarcoidosis. The aim of this study was to assess the elemental composition of exhaled breath condensate (EBC) in patients with interstitial lung diseases (ILDs) of unknown etiology and healthy subjects as an indirect evaluation of tissue burden, which could improve our understanding of the role of metals in the pathogenesis of ILDs. EBC was obtained from 33 healthy subjects, 22 patients with sarcoidosis, 15 patients with non-specific interstitial pneumonia (NSIP) and 19 with IIPs. Trace elements and toxic metals in the samples were measured by means of inductively coupled plasma-mass spectrometry. There are only small overall differences in the EBC levels of a number of metallic elements among patients with idiopathic pulmonary fibrosis (IPF), NSIP or sarcoidosis, and no pattern is capable of distinguishing them with a high degree of sensitivity and specificity. However, a pattern of pneumotoxic (Si, Ni) and essential elements (Zn, Se and Cu) with the addition of Co distinguished the patients with ILDs from healthy non-smokers with relatively high degrees of sensitivity (96.4%) and specificity (90.9%). Assessing the elemental composition of EBC in patients with different ILDs seems to provide useful information. The non-invasiveness of the EBC method makes it suitable for patients with pulmonary diseases, although further studies are required to confirm the usefulness of this approach and to better understand the underlying pathophysiological processes.

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“…Several reports have noted associations with occupations such as agriculture, metalworking, firefighting, and the handling of building supplies (3,30,32,38). The association of sarcoidosis with these occupations raises the possibility that disease may be caused by exposure to microbial bioaerosols, including inorganic particles, insecticides, and aerosols from moldy environments (3,32,35,39). Sarcoidosis also demonstrates a seasonal and geographic variability (12,29,34,50).…”

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confidence: 99%

Cellular Responses to Mycobacterial Antigens Are Present in Bronchoalveolar Lavage Fluid Used in the Diagnosis of Sarcoidosis

et al. 2009

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Considerable evidence supports the concept that CD4؉ T cells are important in sarcoidosis pathogenesis, but the antigens responsible for the observed Th1 immunophenotype remain elusive. The epidemiologic association with bioaerosols and the presence of granulomatous inflammation support consideration of mycobacterial antigens. To explore the role of mycobacterial antigens in sarcoidosis immunopathogenesis, we assessed the immune recognition of mycobacterial antigens, the 6-kDa early secreted antigenic protein (ESAT-6) and catalase-peroxidase (KatG), by T cells derived from bronchoalveolar lavage (BAL) fluid obtained during diagnostic bronchoscopy. We report the presence of antigen-specific recognition of ESAT-6 and KatG in T cells from BAL fluid of 32/44 sarcoidosis subjects, compared to 1/27 controls (P < 0.0001). CD4

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Job and Industry Classifications Associated With Sarcoidosis in a Case–Control Etiologic Study of Sarcoidosis (ACCESS)

Abstract: In this study, we found that exposures in particular occupational settings may contribute to sarcoidosis risk.

Cited by 112 publications

References 15 publications

Prevalence of sarcoidosis in Switzerland is associated with environmental factors

Prevalence of sarcoidosis in Switzerland is associated with environmental factors

Metallic elements in exhaled breath condensate of patients with interstitial lung diseases

Cellular Responses to Mycobacterial Antigens Are Present in Bronchoalveolar Lavage Fluid Used in the Diagnosis of Sarcoidosis

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