BackgroundJob satisfaction means how happy and content people are with their job. Workers who are satisfied with their jobs tend to get more work done and give better care. When workers are not happy at work, they are also not productive as well and many of them leave their jobs. This study aimed to address the level of job satisfaction and associated factors among healthcare setting staff in Ethiopia from 2012 to 2022.MethodsPubMed, Scopus, Cochrane, Google Scholar and African Index Medicus databases have been searched based on preferred reporting items for systematic review and meta‐analysis. Pooled estimate of job satisfaction level was done using the random effects model after significant heterogeneities have been checked by subgroup analysis. Publication bias was checked using funnel plot.ResultsPooled satisfaction level of healthcare workers in Ethiopia was 50.31%. Factors associated were autonomy (pooled odds ratio (POR) = 5.79, 95% CI: 1.99–16.90), training (POR = 3.09, 95% CI: 1.69–5.67), organizational policy (POR = 4.71, 95% CI: 2.09–10.61), reward (POR = 4.58,95% CI: 1.51–13.84), payment (POR = 3.89, 95% CI: 1.77–8.54), supervision (POR = 5.34, 95% CI: 3.72–7.67) and work environment (POR = 5.44, 95% CI: 2.80–10.58).ConclusionAbout half of healthcare staff in Ethiopia's healthcare settings were satisfied with their job. This result was lower than the job satisfaction level of other parts of the world, even in African countries. Healthcare settings should strive to provide a good working environment, with training opportunities, adequate payment, supportive supervision and conducive organizational policy.