Although the meaningful relationship between organizational culture and employee performance is a widely-researched topic, there is scant research available how organizational culture impacts on employees’ perceived stress in the workplace, affecting their performance. This might cause a difficulty to guide practitioners as to what organizational elements can be applied to reduce employee perceived stress. To add the level of robustness and fill the gap in the literature, the present research explores the effect of organizational culture with employee competency on workers’ perceived stress which has emerged as a common occupational disease and affected employees psychologically and physically; thus, affecting their performance. Using 641 responses, the statistical findings of the present research insists that HR practitioners should match the type of organizational culture and employee competency situationally to reduce employee stress. The current authors suggest that organizations desiring the adaptability competencies (Professional competency) for their employees should build a clan organizational culture. In contrast, organizations should encourage a market organizational culture for their employees who possess customer orientation competency (Simply result-oriented competency). The research outcomes provide additional knowledge to the existing literature, enhance academicians’ understanding of the research topic, and serve as a significant knowledge base for further empirical research.