John Brooks Henderson, Jr., Cuba, Trinidad, 1920

Henderson, John

doi:10.5962/bhl.title.142188

Cited by 7 publications

(16 citation statements)

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“…In an animal model of asthma, montelukast not only prevent allergen-induced airway changes, but also reverse structural changes such as airway smooth muscle cell layer thickening and subepithelial fibrosis, which are resistant to glucocorticoids [21]. These findings could contribute to a better understanding of the pathophysiology of airway remodeling and be relevant for the management of asthmatic patients as they might clarify the role of CysLT 1 receptor antagonists in asthma therapy.…”

Section: Antileukotrienes In Asthmamentioning

confidence: 93%

“…Montelukast reduces allergeninduced lung inflammation and fibrosis in an animal model of the airway remodeling changes observed in patients with persistent asthma [21]. LTB 4 has no direct bronchoconstrictor effect in healthy or asthmatic subjects and the lack of effect of LTB 4 receptor antagonists in allergen-induced early or late phase airway obstruction in patients with asthma [47] argues against an important role for LTB 4 in acute bronchoconstriction.…”

Section: Biological Effects Of Leukotrienes In the Airwaysmentioning

confidence: 98%

“…CysLT 1 receptor antagonists have significant anti-airway remodeling effects in an animal model of asthma [21] and inhibitory effects on myofibroblasts in patients with a asthma [22]. LTB 4 , a potent chemoattractant for neutrophils, is functionally involved in severe asthma and asthma exacerbations [5], but its role in less severe chronic stable asthma is less known.…”

Section: Leukotrienes (Lts) Including Ltb 4 and Cysteinyl-lts (Cysltmentioning

confidence: 99%

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Leukotrienes, Antileukotrienes and Asthma

Montuschi

2008

MRMC

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Leukotrienes (LTs), including LTB(4) and cysteinyl-LTs (CysLTs) (LTC(4), LTD(4), and LTE(4)), are potent inflammatory lipid mediators which are derived from 5-lipoxygenase activity. CysLTs, which stimulate CysLT(1) and CysLT(2) receptor subtypes, are functionally involved in the pathophysiology of asthma. Selective CysLT(1) receptor antagonists are effective anti-asthmatic drugs. CysLT(1) receptor antagonists have been developed from leukotriene structural analogs, analogs of FPL 55712, a chromone carboxylic acid, and by random screening of corporate compound banks. This review will examine the biosynthesis, metabolism and mechanism of action of leukotrienes, their role in asthma, the therapeutic implications of the leukotriene pathway inhibition for asthma, and the medicinal chemistry strategies that have been exploited in the design of potent and selective CysLT(1) receptor antagonists.

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Section: Antileukotrienes In Asthmamentioning

confidence: 93%

Section: Biological Effects Of Leukotrienes In the Airwaysmentioning

confidence: 98%

Section: Leukotrienes (Lts) Including Ltb 4 and Cysteinyl-lts (Cysltmentioning

confidence: 99%

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Leukotrienes, Antileukotrienes and Asthma

Montuschi

2008

MRMC

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“…Numerous experimental and theoretical studies have been conducted on the PEO3: LiCF3SO3 electrolyte system [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Experimental research has demonstrated that, depending on the preparation conditions including particularly the temperature, both crystalline and amorphous phases of PEO3: LiCF3SO3 can be formed [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The difference in conductivity between the crystalline and amorphous phases has been also studied experimentally [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…The atomic structure of crystalline PEO3:LiCF3SO3 was determined by both powder and single crystal X-ray diffraction (XRD) measurements [5,14]. Theoretical investigations for the local structure of short chain PEO3:LiCF3SO3 were also performed [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Ab initio calculations of the atomic and electronic structures of crystalline PEO3:LiCF3SO3 electrolytes

Xue

Liu

Dang

et al. 2016

Computational Materials Science

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The PEO3:LiCF3SO3 polymer electrolyte has attracted significant research due to its enhanced stability at the lithium/polymer interface of high conductivity polymer batteries. Experimental studies have shown that, depending on the preparation conditions, both the PEO3:LiCF3SO3 crystalline complex and the PEO3:LiCF3SO3 amorphous phase can be formed. However, previous theoretical investigations focused on the short chain amorphous PEO3:LiCF3SO3 system. We report ab initio density-functional-theory calculations of crystalline PEO3:LiCF3SO3. The calculated results about the bonding configuration, electronic structures, and conductivity properties are in good agreement with the experimental measurements.

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Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response

Stadlmayr,

Peter,

Millesi

et al. 2023

Adv Healthcare Materials

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Peripheral nerve reconstruction through the employment of nerve guidance conduits with Trichonephila dragline silk as a luminal filling has emerged as an outstanding preclinical alternative to avoid nerve autografts. Yet, it remains unknown whether the outcome is similar for silk fibers harvested from other spider species. This study compares the regenerative potential of dragline silk from two orb‐weaving spiders, Trichonephila inaurata and Nuctenea umbratica, as well as the silk of the jumping spider Phidippus regius. Proliferation, migration, and transcriptomic state of Schwann cells seeded on these silks are investigated. In addition, fiber morphology, primary protein structure, and mechanical properties are studied. The results demonstrate that the increased velocity of Schwann cells on Phidippus regius fibers can be primarily attributed to the interplay between the silk's primary protein structure and its mechanical properties. Furthermore, the capacity of silk fibers to trigger cells toward a gene expression profile of a myelinating Schwann cell phenotype is shown. The findings for the first time allow an in‐depth comparison of the specific cellular response to various native spider silks and a correlation with the fibers’ material properties. This knowledge is essential to open up possibilities for targeted manufacturing of synthetic nervous tissue replacement.

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John Brooks Henderson, Jr., Cuba, Trinidad, 1920

Cited by 7 publications

References 0 publications

Leukotrienes, Antileukotrienes and Asthma

Leukotrienes, Antileukotrienes and Asthma

Ab initio calculations of the atomic and electronic structures of crystalline PEO3:LiCF3SO3 electrolytes

Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response

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