John C. Bailar, Jr. (1904–1991): father of coordination chemistry in the United States

Kauffman, George B.; Girolami, Gregory S.; Busch, Daryle H.

doi:10.1016/0010-8545(93)80022-w

Cited by 6 publications

(1 citation statement)

References 223 publications

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“…[11] The shifting of the CH 2 strengths of the methylene groups in triflupromazine to lower frequencies of 1320-1340 cm À 1 reveals the existence of a bond within nitrogen and copper atoms. [12] This is confirmed by the emergence of a distinct (MÀ N) band in the 590-700 cm À 1 . [13] The free amino acid's symmetrical υ (COO-) band occurs around 1395-1430 cm À 1 in stretching vibration modes, while the anti-symmetric υ (C = O) band occurs around 1600-1660 cm À 1 .…”

Section: Analyses Of Synthesized Copper(ii) Solid Complexesmentioning

confidence: 83%

Synthesis, Characterization, and Biological Evaluation of Cu(II) Complexes Containing Triflupromazine with Glycine and Histidine

Sultan

Elhakim

Shoukry

et al. 2023

Chemistry & Biodiversity

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Two novel copper (II) complexes [Cu(TFP)(Gly)Cl] • 2H 2 O complex (1) and [Cu(TFP)(His)Cl] • 2H 2 O complex (2) are synthesized, where TFP stands for trifluropromazine, Gly. represents glycine, and His. is histidine. Chemical composition, IR, mass spectra, and magnetic susceptibility tests are performed. Complex binding with macromolecules was investigated using UV-vis, viscosity, gel electrophoresis, and fluorescence quenching. Fluorescence spectroscopy revealed that each complex could replace ethidium bromide (EB). These complexes exhibit grooved, non-covalent, and electrostatic interactions with CT-DNA. Spectroscopy analysis of the BSA interaction showed that complexes bind to protein (K b values for (1) is 5.89 × 10 3 M À 1 and for (2) is 9.08 × 10 3 M À 1 ) more strongly than CT-DNA (K b values for (1) is 5.43 × 10 3 M À 1 and for (2) is 7.17 × 10 3 M À 1 ). Molecular docking analysis and spectral absorption measurements showed high agreement. Antimicrobial, antioxidant, and anti-inflammatory properties were tested in vitro. The druggability of complex (2) should be tested in vivo as it is more biologically active.

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Section: Analyses Of Synthesized Copper(ii) Solid Complexesmentioning

confidence: 83%