The 19th century saw the important transformation of modern Western concepts into Chinese lexical resources. The missionaries were the initiators and important driving force for the translation of Western books into Chinese in modern China. They promoted ‘translating terms’ and ‘coining terms’ in their translations of Western books and the compilation of dictionaries with the cooperation of Chinese intellectuals. Their work provided a tangible ‘word’ carrier of ‘concepts’ for disseminating modern knowledge from the West to the East. Compiled by missionaries, the English–Chinese bilingual dictionaries introduced a brand-new concept of dictionary compilation and changed China’s history of having zidian (字典, character dictionaries) but no cidian (辞典, specialized dictionaries). In particular, John Fryer applied the translation method of creating new words or characters in the translation of chemical terminology. Members of the School and Textbook Series Committee, including John Fryer and Calvin Wilson Mateer, made great contributions to theories and strategies for translation, which keep inspiring Chinese–English translation of terminology and its theoretical construction.