John H. Laragh, MD: Clinician-Scientist

Sealey, Jean E.

doi:10.1093/ajh/hpu110

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Mechanisms Of Bp Control: Linking the Ras To Inflammation1

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2018

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“…Drugs targeting the renin-angiotensin-aldosterone system are widely used in the treatment of hypertension, in large part through the efforts and advances made by John Laragh. 29,30 Dr Laragh discovered the central role of renin in contributing to increases in BP and the associated endorgan damage in hypertension. [31][32][33] This work provided the foundation and rationale for the development of 2 classes of antihypertensive drugs that remain a first-line defense for the treatment of hypertension, ACE inhibitors, and ARBs.…”

Section: Mechanisms Of Bp Control: Linking the Ras To Inflammationmentioning

confidence: 99%

Sex Differences in Hypertension: Where We Have Been and Where We Are Going

Ramirez

Sullivan

2018

American Journal of Hypertension

169

109

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As a result, the well-established gender difference in the prevalence of hypertension is even more pronounced and now extends into the sixth decade of life. The goals of this review are to (i) review the historical clinical trial data and hypertension guidelines from the perspective of both genders and then (ii) review the role of the renin-angiotensin system and T-cell activation in contributing to sex differences in BP control.

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