In this paper, we study an approximate biflatness of
l
1
S
, where
S
is a Clifford semigroup. Indeed, we show that a Clifford semigroup algebra
l
1
S
is approximately biflat if and only if every maximal subgroup of
S
is amenable,
E
S
is locally finite, and
l
1
S
has an approximate identity in
c
00
S
. Moreover, we prove that
l
1
S
is approximately biflat if and only if each maximal subgroup of
S
is amenable for an inverse semigroup
S
such that
E
S
, the set of its idempotent elements, is totally ordered and locally finite.