Joint association between ambient air pollutant mixture and pediatric asthma exacerbations

Puvvula, Jagadeesh; Poole, Jill; González, Sandra; Rogan, Eleanor G.; Gwon, Yeongjin; Rorie, Andrew; Ford, Linda; Bell, Jesse E.

doi:10.1097/ee9.0000000000000225

Cited by 13 publications

(7 citation statements)

References 63 publications

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“…In Shanghai, according to Liu et al, short-term exposure to ambient air pollutants raises the frequency of pediatric visits to the Asthma Emergency Department (ED) ( 39 ). According to the findings of Puvvula et al, exposure to air pollution mixtures (primarily PM2.5, pollen, and mold) can increase emergency room (ED) visits for children with asthma ( 40 ). To sum up, air pollution (particularly PM2.5) leads to an increase in the need for asthma-related healthcare, and PM2.5 has an impact on the development and aggravation of childhood asthma.…”

Section: Resultsmentioning

confidence: 99%

The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication

Zhang,

Yin,

Zheng

2023

Front. Pediatr.

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Much is known about the link between air pollution and asthma in adults, particularly fine particulate matter (PM2.5). Studies have found that certain levels of fine PM2.5 can increase airway responsiveness and worsen asthma. PM2.5 may play a role in the onset and exacerbation of childhood asthma. However, there is little in the literature on how PM2.5 affects asthma attacks and exacerbations in children. Asthma is a common chronic disease in children, and air pollution can aggravate it. The effect of PM2.5 on childhood asthma needs further research. By evaluating, reviewing, and collating existing results in this area, this paper aims to explore the relationship between PM2.5 and asthma onset and exacerbation in children.

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Section: Resultsmentioning

confidence: 99%

The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication

Zhang,

Yin,

Zheng

2023

Front. Pediatr.

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“…The study also conducted age-based subgroup analyses of children (0–14) and adults (>14) and found children with asthma were more susceptible to outdoor air pollution ( Huang et al 2021 ). However, various other time-series studies using air pollutants have observed a lag effect with varying results from 0–5 days ( Ostro et al 2001 , Lee et al 2006 , Halonen et al 2008 , Khalili et al 2018 , Lu et al 2020 , Puvvula et al 2022 ) to 6–7 days ( Chien et al 2018 , Dabrowiecki et al 2022). In general, lag effects past 7 days are typically not observed, though Gu et al (2004) found a lag of 7–10 days.…”

Section: Discussionmentioning

confidence: 96%

Seasonal extreme temperatures and short-term fine particulate matter increases child respiratory hospitalizations in a sparsely populated region of the intermountain western United States

Landguth,

Knudson,

Graham

et al. 2023

Preprint

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Background Western Montana, USA, experiences complex air pollution patterns with predominant exposure sources from summer wildfire smoke and winter wood smoke. In addition, climate change related temperatures events are becoming more extreme and expected to contribute to increases in hospital admissions for a range of health outcomes. Few studies have evaluated these exposures (air pollution and temperature) that often occur simultaneously and may act synergistically on health. Methods We explored short-term exposure to air pollution on childhood respiratory health outcomes and how extreme temperature or seasonal period modify the risk of air pollution-associated hospitalizations. The main outcome measure included all respiratory-related hospital admissions for three categories: asthma, lower respiratory tract infections (LRTI), and upper respiratory tract infections (URTI) across western Montana for all individuals aged 0–17 from 2017–2020. We used a time-stratified, case-crossover analysis and distributed lag models to identify sensitive exposure windows of fine particulate matter (PM2.5) lagged from 0 (same-day) to 15 prior-days modified by temperature or season. Results Short-term exposure increases of 1 µg/m3 in PM2.5 were associated with elevated odds of all three respiratory hospital admission categories. PM2.5 was associated with the largest increased odds of hospitalizations for asthma at lag 7–13 days [1.87(1.17–2.97)], for LRTI at lag 6–12 days [2.18(1.20–3.97)], and for URTI at a cumulative lag of 13 days [1.29(1.07–1.57)]. The impact of PM2.5 varied by temperature and season for each respiratory outcome scenario. For asthma, PM2.5 was associated most strongly during colder temperatures [3.11(1.40–6.89)] and the winter season [3.26(1.07–9.95)]. Also in colder temperatures, PM2.5 was associated with increased odds of LRTI hospitalization [2.61(1.15–5.94)], but no seasonal effect was observed. Finally, 13 days of cumulative PM2.5 prior to admissions date was associated with the greatest increased odds of URTI hospitalization during summer days [3.35(1.85–6.04)] and hotter temperatures [1.71(1.31–2.22)]. Conclusions Children’s respiratory-related hospital admissions were associated with short-term exposure to PM2.5. PM2.5 associations with asthma and LRTI hospitalizations were strongest during cold periods, whereas associations with URTI were largest during hot periods. Classification : environmental public health, fine particulate matter air pollution, respiratory infections

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“…The same study also conducted age-based subgroup analyses of children (0–14) and adults (> 14) and found children with asthma were more susceptible to outdoor air pollution [ 36 ]. However, various other time-series studies using air pollutants have observed a lag effect with varying results from 0–5 days [ 33 , 39 , 51 , 58 , 68 , 72 ] to 6–7 days [ 15 ]. Our study, using the DLM, places the PM 2.5 associated increased risk in children’s asthma events on the higher delayed end of these studies at a weekly average lag of 7–13 days.…”

Section: Discussionmentioning

confidence: 99%

Seasonal extreme temperatures and short-term fine particulate matter increases pediatric respiratory healthcare encounters in a sparsely populated region of the intermountain western United States

Landguth,

Knudson,

Graham

et al. 2024

Environ Health

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Background Western Montana, USA, experiences complex air pollution patterns with predominant exposure sources from summer wildfire smoke and winter wood smoke. In addition, climate change related temperatures events are becoming more extreme and expected to contribute to increases in hospital admissions for a range of health outcomes. Evaluating while accounting for these exposures (air pollution and temperature) that often occur simultaneously and may act synergistically on health is becoming more important. Methods We explored short-term exposure to air pollution on children’s respiratory health outcomes and how extreme temperature or seasonal period modify the risk of air pollution-associated healthcare events. The main outcome measure included individual-based address located respiratory-related healthcare visits for three categories: asthma, lower respiratory tract infections (LRTI), and upper respiratory tract infections (URTI) across western Montana for ages 0–17 from 2017–2020. We used a time-stratified, case-crossover analysis with distributed lag models to identify sensitive exposure windows of fine particulate matter (PM2.5) lagged from 0 (same-day) to 14 prior-days modified by temperature or season. Results For asthma, increases of 1 µg/m3 in PM2.5 exposure 7–13 days prior a healthcare visit date was associated with increased odds that were magnified during median to colder temperatures and winter periods. For LRTIs, 1 µg/m3 increases during 12 days of cumulative PM2.5 with peak exposure periods between 6–12 days before healthcare visit date was associated with elevated LRTI events, also heightened in median to colder temperatures but no seasonal effect was observed. For URTIs, 1 unit increases during 13 days of cumulative PM2.5 with peak exposure periods between 4–10 days prior event date was associated with greater risk for URTIs visits that were intensified during median to hotter temperatures and spring to summer periods. Conclusions Delayed, short-term exposure increases of PM2.5 were associated with elevated odds of all three pediatric respiratory healthcare visit categories in a sparsely population area of the inter-Rocky Mountains, USA. PM2.5 in colder temperatures tended to increase instances of asthma and LRTIs, while PM2.5 during hotter periods increased URTIs.

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Joint association between ambient air pollutant mixture and pediatric asthma exacerbations

Cited by 13 publications

References 63 publications

The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication

The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication

Seasonal extreme temperatures and short-term fine particulate matter increases child respiratory hospitalizations in a sparsely populated region of the intermountain western United States

Seasonal extreme temperatures and short-term fine particulate matter increases pediatric respiratory healthcare encounters in a sparsely populated region of the intermountain western United States

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