Joint Association of Genome-Wide Association Study-Identified Susceptibility Loci and Dietary Patterns in Risk of Renal Cell Carcinoma Among Non-Hispanic Whites

Melkonian, Stephanie C.; Daniel, Carrie R.; Hildebrandt, Michelle A.T.; Tannir, Nizar M.; Ye, Yuanqing; Chow, Wong‐Ho; Wood, Christopher G.; Wu, Xifeng

doi:10.1093/aje/kwu158

Cited by 15 publications

(23 citation statements)

References 46 publications

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“…Except our previous study with a smaller sample size which reported a non-statistically significant protective effect on renal cell carcinoma20, there has been no other studies on the “Tex-Mex” dietary pattern and cancer. The mechanism(s) linking high adherence to the “Tex-Mex” pattern with a decreased risk of lung cancer is unclear.…”

Section: Discussionmentioning

confidence: 55%

“…The number of factors that best represented the data was chosen on the basis of eigenvalues greater than one, identification of a break point in the scree plot, interpretability, and our previous dietary pattern analysis on renal cell carcinoma20. We identified three factors that best represented the dietary input data, and these three dietary patterns were identical to the three patterns identified in our previous study of renal cell carcinoma20. The final analysis was restricted only to the three chosen factors.…”

Section: Methodsmentioning

confidence: 99%

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Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

Heymach

Wen

et al. 2016

Sci Rep

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Reducing lung cancer risk by modifying diet is highly desirable. We investigated whether different U.S. dietary patterns were associated with lung cancer risk. Dietary patterns were derived using exploratory factor analysis for 2139 non-small cell lung cancer (NSCLC) cases and 2163 frequency-matched controls. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Highest adherence (highest vs. lowest quintile) to the “Tex-Mex”, “fruits and vegetables”, and “American/Western” patterns was associated with a 55% reduced (OR = 0.45; 95% CI = 0.37–0.56; P < 0.001), 32% reduced (OR = 0.68; 95% CI = 0.55–0.85; P = 0.001), and 45% increased (OR = 1.45; 95% CI = 1.18–1.78; P < 0.001) risk of lung cancer, respectively. The effects were stronger for squamous cell carcinoma and ever smokers for the “fruits and vegetables” pattern, and stronger for other non-small cell lung cancer and never smokers for the “American/Western” pattern. Among six genome-wide association (GWA) studies-identified lung cancer susceptibility loci assessed, a variant (rs2808630) of the C-reactive protein gene modified the associations for the “fruits and vegetables” (P for interaction = 0.03) and “American/Western” (P for interaction = 0.02) patterns. Our study first showed that the “Tex-Mex” dietary pattern was associated with a reduced lung cancer risk. Also, the “fruits and vegetables” and “American/Western” patterns affected lung cancer risk, and the effects were further modified by host genetic background.

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Section: Discussionmentioning

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

Heymach

Wen

et al. 2016

Sci Rep

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“…The Tex‐Mex pattern is based on an American regional cuisine which is quite specific for the area where our study was conducted. Except for two studies on renal cancer risk and lung cancer risk, no studies reported about this pattern before. The Tex‐Mex pattern contains potentially beneficial components such as legumes, as well as potentially harmful components such as red meat and pizza.…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and risk of recurrence and progression in non‐muscle‐invasive bladder cancer

Westhoff¹,

Kiemeney³

et al. 2017

Intl Journal of Cancer

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The association of dietary factors with urinary bladder cancer prognosis has scarcely been investigated, and results of studies conducted to date are inconsistent. We investigated whether empirically derived dietary patterns are associated with risks of recurrence and progression in non-muscle-invasive bladder cancer (NMIBC) patients. Data from 595 newly diagnosed NMIBC patients from an ongoing prospective cohort study were used to derive dietary patterns using exploratory factor analysis. Factor scores were calculated and then categorized in sex-specific tertiles. Multivariable-adjusted proportional hazards regression models were used to estimate hazard ratios and 95% confidence intervals for the associations between tertiles of adherence to the dietary patterns and risks of recurrence and progression. We identified four dietary patterns: "fruits and vegetables," "Western," "low-fat," and "Tex-Mex." Patients in the highest tertile of adherence to the Western pattern experienced a 1.48 times higher risk of recurrence (95% CI 1.06-2.06) compared to patients in the lowest tertile. No statistically significant associations of a Western diet with risk of progression or of the other dietary patterns with risk of recurrence and progression were found. Overall, we found that adherence to a Western diet was associated with a higher risk of recurrence but further studies are needed to confirm our findings.

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“…A cut-off was defined at the 75th percentile plus 1.5 times the interquartile range (3553.3 kcal) and the 25th percentile minus 1.5 times the interquartile range (190.9 kcal) [27]. This led to the exclusion of two FFQs with an over-reporting of energy intake (4250.3 kcal, 5414.3 kcal).…”

Section: Methodsmentioning

confidence: 99%

Relative validation of a food frequency questionnaire to estimate food intake in an adult population

Steinemann

Grize

Ziesemer

et al. 2017

Food & Nutrition Research

106

101

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Background: Scientifically valid descriptions of dietary intake at population level are crucial for investigating diet effects on health and disease. Food frequency questionnaires (FFQs) are the most common dietary tools used in large epidemiological studies. Objective: To examine the relative validity of a newly developed FFQ to be used as dietary assessment tool in epidemiological studies. Design: Validity was evaluated by comparing the FFQ and a 4-day weighed food record (4-d FR) at nutrient and food group levels, Spearman’s correlations, Bland–Altman analysis and Wilcoxon rank sum tests were used. Fifty-six participants completed a paper format FFQ and a 4-d FR within 4 weeks. Results: Corrected correlations between the two instruments ranged from 0.27 (carbohydrates) to 0.55 (protein), and at food group level from 0.09 (soup) to 0.92 (alcohol). Nine out of 25 food groups showed correlations > 0.5, indicating moderate validity. More than half the food groups were overestimated in the FFQ, especially vegetables (82.8%) and fruits (56.3%). Water, tea and coffee were underestimated (–14.0%). Conclusions: The FFQ showed moderate relative validity for protein and the food groups fruits, egg, meat, sausage, nuts, salty snacks and beverages. This study supports the use of the FFQ as an acceptable tool for assessing nutrition as a health determinant in large epidemiological studies.

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Joint Association of Genome-Wide Association Study-Identified Susceptibility Loci and Dietary Patterns in Risk of Renal Cell Carcinoma Among Non-Hispanic Whites

Cited by 15 publications

References 46 publications

Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

Dietary patterns and risk of recurrence and progression in non‐muscle‐invasive bladder cancer

Relative validation of a food frequency questionnaire to estimate food intake in an adult population

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