Joint Changes after Overuse and Peak Overloading of Rabbit KneesIn Vivo

Abstract

T h e effect of overuse and overuse combined with axial peak overloading on the knee joints of living rabbits has been investigated. A specially constructed apparatus was used for this purpose. Phvsical and biochemical changes are reported and include:1. Early and progressive damage to the articular cartilage surface shown 2. The presence of an increased amount of prostaglandin E in the 3. A reduction of cyclic 3'-5' adenosine monophosphate in the sub- 4.Late changes which were consistent with osteoarthritis.These changes were found only in the joints subjected to simultaneous overuse and peak overloading.The results suggest that:by the scanning electron microscope.synovial fluid.chondral hone.1. Cartilage damage and chemical changes in the suhchondral bone are simultaneous and are both responsible for eventual degenerative changes. 2. Frictional overuse alone does not seem to be responsible for the production of osteoarthritis.

Sports, Joint Injury, and Posttraumatic Osteoarthritis

“…95 Repeated in vivo movement of rabbit knee joints from 80°of flexion to full extension and impact loading at the point of full extension caused articular cartilage damage, including formation of chondrocyte clusters, fibrillation of the matrix, thickening of subchondral bone, and penetration of subchondral capillaries into the calcified zone of articular cartilage. 32 The extent of cartilage damage appeared to increase with longer periods of repetitive overloading and deterioration of the cartilage continued after cessation of excessive loading. This latter finding suggests that some cartilage damage due to impact loading is not immediately visible.…”

“…32,106 Cyclic loading of human cartilage samples in vitro caused surface fibrillation. 106 In another in vitro study, impact loading of bovine metacarpal phalangeal joints combined with joint motion caused disruption of articular cartilage.…”

Comparison of Heel-rocking Time Between Young Women and Elderly Women

“…이로 인한 반복적인 충격과 스 트레스 파들은 퇴행성 골다공증 유발에 주요 원인들이라고 제기 되고 있다 [8][9]. 또한 관절염은 질병으로부터 야기되는 것이 아 닌 역학적 부하를 서투르게 다룬 것이 주요한 원인이라고 지적되 었다 [10].…”

Micromechanical properties of chondrocytes and chondrons: relevance to articular cartilage tissue engineering

“…abnormal mechanical environment within the tissue, created in cases of high joint impact or due to an accumulation of small repeated loading events, significantly affects cellular behavior and may result in pathological extracellular matrix (ECM) synthesis and apoptosis [Dekel and Weissman 1978;Radin et al 1984;Ehrlich et al 1987;Radin et al 1991;Jeffrey et al 1995;J. Borrelli et al 2003].…”