Joint Disease Associated With Acromegaly*†

Articular Manifestations of Acromegaly

“…Three of these four patients had long-standing acromegaly refractory to treatment. Patients who completely responded (CR) to treatment of acromegaly had less severe arthropathy: 14 -+ + =severe.…”

Ultrasonographic evidence of joint thickening reversibility in acromegalic patients treated with lanreotide for 12 months

“…The articular manifestations, which include articular involvement and enthesopathy, affect the great majority of patients with acromegaly and is a leading cause of morbidity and functional disability (Waine et al ., 1945; Kellgren et al ., 1952; Bluestone et al ., 1971). Degenerative disease is the most common manifestation, and crepitus on clinical examination the most common finding (Bluestone et al ., 1971; Kellgren et al ., 1952; Detenbeck et al ., 1973; Holt, 1981).…”

“…Degenerative disease is the most common manifestation, and crepitus on clinical examination the most common finding (Bluestone et al ., 1971; Kellgren et al ., 1952; Detenbeck et al ., 1973; Holt, 1981). The acromegalic arthropathy affects both axial and peripheral sites and is generally non‐inflammatory (Detenbeck et al ., 1973; Holt, 1981), although it frequently develops features of osteoarthritis in later stages of the disease (Waine et al ., 1945; Kellgren et al ., 1952; Bluestone et al ., 1971; Detenbeck et al ., 1973; Holt, 1981; Johanson et al ., 1983).…”