Joint Diseases

Robba, Tiziana; Tosco, Paolo; Parisi, Simone; Ramieri, Guglielmo; Fusaro, Enrico; Faletti, Riccardo; Tanteri, Giulia

doi:10.1007/978-3-030-25421-6_8

Cited by 2 publications

(1 citation statement)

References 209 publications

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“…Total protein was also estimated in plasma of control and test groups. Various studies suggested that pro-in ammatory markers like tumor necrosis factor alpha (TNF-α) and other markers of in ammation such as leukotriene B4, prostaglandin E2 and platelet activating agents may increase the total protein concentration in plasma [32][33][34] reported that, total concentration of protein in non-painful and effusion free joints is signi cantly lower than total concentration of protein in painful joints and joints effusion [35][36][37] due to the fact that healthy synovial membrane is impermeable to the high molecular weight plasma proteins [38]. The permeability of plasma proteins increases with the gradual increase in the in ammation and perforation of synovial membrane [39].…”

Section: Total Proteinmentioning

confidence: 99%

Chronic Inflammatory Pain Management by BDNF Modulation: A Comparative Study of Gabapentin, Indomethacin and Their Combination on Arthritis Rat Model

Khurshid

Razzak

Simjee

2021

Preprint

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Brain derived neurotropic factors (BDNF) can be secreted either as a pro-BDNF or a mature form (mBDNF) through γ-amino-butyric acid (GABAA) receptors activation. Depolarization of GABA neurons in spinal cord can be mediated through N-methyl-D-aspartate (NMDA) receptor due to the exogenous secretion of over expressed BDNF. This over expressed BDNF further modulate the excitation and sensitization of nociceptors. We investigated the modulation of BDNF by GABAA agonist i.e., gabapentin, indomethacin (non-steroidal anti-inflammatory) and their low-dose combination on adjuvant-induced inflammatory arthritis. Mycobacterium tuberculosis H37Ra strain, as adjuvant, was injected in the tail base of female Sprague-Dawley rats. Gabapentin (5 mg/kg), indomethacin (5 mg/kg) and low dose combination of gabapentin (1.5 mg/kg) + indomethacin (2.5 mg/kg) were used. Paw edema was measure by plethysmometer and chronic pain was measured by plantar apparatus. Nitric oxide, peroxide and superoxide dismutase levels were also measured to analyze the free radical and antioxidant balance in different treatment groups along with the total protein concentration. Significant reduction of nitric oxide, peroxide as well as total protein concentration was found in low dose combination. Immunohistochemistry data also showed that the low dose combination has more potential in lowering the BDNF expression in cortex as well as in hippocampus region of brain as compared to their mono therapies. Our study suggested that low-dose combination of gabapentin and indomethacin has a significant impact on lowering the chronic and its associated markers as compare to their monotherapy. Thus indicated the additive effects of the combination therapy on neuropathic pain.

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Section: Total Proteinmentioning

confidence: 99%

Chronic Inflammatory Pain Management by BDNF Modulation: A Comparative Study of Gabapentin, Indomethacin and Their Combination on Arthritis Rat Model

Khurshid

Razzak

Simjee

2021

Preprint

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Idiopathic Condylar Resorption-a Review

Sangai

Banerjee

Shenoy

2021

ijsr

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Idiopathic condylar resorption (ICR) of the temporomandibular joint (TMJ) is a condition that is often esthetically and functionally altering, characterized by progressive resorption of the TMJ condylar heads, without a known cause. Studies suggest that patients with ICR remain undiagnosed and unrecognized in the orthodontic clinic owing to the poorly understood etiology of the disease and lack of diagnostic tools. ICR often causes occlusal and skeletal changes, TMJ dysfunction and pain, and maxillofacial deformities. Therefore, precise diagnosis of the disease and proper treatment plan is essential.

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Joint Diseases

Cited by 2 publications

References 209 publications

Chronic Inflammatory Pain Management by BDNF Modulation: A Comparative Study of Gabapentin, Indomethacin and Their Combination on Arthritis Rat Model

Chronic Inflammatory Pain Management by BDNF Modulation: A Comparative Study of Gabapentin, Indomethacin and Their Combination on Arthritis Rat Model

Idiopathic Condylar Resorption-a Review

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