Joint effect of multiple air pollutants on lipid profiles in obese and normal-weight young adults: The key role of ozone

Zhang, Wenlou; Liu, Junxiu; Hu, Dayu; Li, Luyi; Cui, Liyan; Xu, Jianfeng; Wang, Wanzhou; Deng, Furong; Guo, Xinbiao

doi:10.1016/j.envpol.2021.118247

Cited by 15 publications

(17 citation statements)

References 49 publications

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“…higher LDL-p concentrations (≥p75), although the associations between air pollutants and the standard LDL-c measures were null. These findings are in line with previous studies suggesting that air pollution might negatively impact blood lipids in the general population, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] and may be a potential contributor to air pollution-related CVD risk. In fact, low HDL-c is a well-established atherosclerotic CVD risk factor, 34 whereas lower HDL and higher LDL particle numbers have also been associated with increasing cardiovascular events.…”

Section: Discussionsupporting

confidence: 93%

“…In this regard, several previous epidemiological studies have explored the relationships between the exposure to several ambient air pollutants and blood lipid levels and the presence of dyslipidaemia. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] However, most of this evidence has relied on standard lipid measures. Standard lipid panels measure the cholesterol or triglyceride content (in concentration per decilitre) carried by each lipoprotein class, rather than the numbers of these particles.…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in lipid metabolism could be another potential pathway in the association between air pollution and arteriosclerosis. In this regard, several previous epidemiological studies have explored the relationships between the exposure to several ambient air pollutants and blood lipid levels and the presence of dyslipidaemia 6–24 . However, most of this evidence has relied on standard lipid measures.…”

Section: Introductionmentioning

confidence: 99%

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Association between exposure to air pollution and blood lipids in the general population of Spain

Valdés,

Doulatram‐Gamgaram,

Maldonado‐Araque

et al. 2023

Eur J Clin Investigation

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Background and AimsWe aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain.MethodsWe included 4647 adults (>18 years), participants in the national, cross‐sectional, population‐based di@bet.es study, conducted in 2008–2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced 1H‐NMR lipoprotein test (Liposcale®). Participants were assigned air pollution concentrations for particulate matter <10 μm (PM10), <2.5 μm (PM2.5) and nitrogen dioxide (NO2), corresponding to the health examination year, obtained by modelling combined with measurements taken at air quality stations (CHIMERE chemistry‐transport model).ResultsIn multivariate linear regression models, each IQR increase in PM10, PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL‐c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL‐p) concentrations (p < .001 for all associations). In multivariate logistic regression, there was a significant association between PM10, PM2.5 and NO2 concentrations and the odds of presenting low HDL‐c (<40 mg/dL), low HDL‐p (<p25) and higher LDL particle (LDL‐p) concentrations (≥p75). In subgroup analyses there were stronger associations between PM10 and NO2 and low HDL‐p in men (p for interaction .008 and .034), and between NO2 and low HDL‐p in individuals with obesity (p for interaction .015).ConclusionsOur study shows an association between the exposure to air pollutants and blood lipids in the general population of Spain, suggesting a link to atherosclerosis.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between exposure to air pollution and blood lipids in the general population of Spain

Valdés,

Doulatram‐Gamgaram,

Maldonado‐Araque

et al. 2023

Eur J Clin Investigation

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“…Raised ozone levels due to higher temperatures and air pollutants from burning fossil fuels also increase cardiorespiratory mortality and morbidity, possibly by increasing cholesterol levels and systemic inflammation. 8 9 Rising incidence of kidney disease and mental illness associated with exposure to urban heat are other devastating effects. 2 4 5 Additionally, increasing urban heat is expected to reduce labour productivity and outdoor working capacity, particularly in the tropics and subtropics.…”

Section: Health Consequences Of Heat Exposurementioning

confidence: 99%

Urban heat: an increasing threat to global health

Tong

Prior

McGregor

et al. 2021

BMJ

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“…Exposure to air pollutants has been variably associated with changes in plasma lipid profile, including a reduction in HDL-C [ 5 ]. HDL can exert a series of protective activities against the development and progression of atherosclerosis [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index Modulates the Impact of Short-Term Exposure to Air Particulate Matter on High-Density Lipoprotein Function

et al. 2022

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Air particulate matter (PM) exposure has been associated with increased cardiovascular risk, especially in obesity. By triggering inflammation and oxidative stress, PM could impact atheroprotection by high-density lipoproteins (HDL). The aim of the study was to assess the relationship between short-term exposure to PM and HDL function, and the modifying effect of body mass index (BMI). Daily exposures to PM10 and PM2.5 of 50 subjects with overweight/obesity and 41 healthy volunteers with BMI < 30 kg/m2 were obtained from fixed monitoring stations. HDL function was assessed as promotion of nitric oxide (NO) release by endothelial cells and reduction in cholesterol in macrophages. HDL-induced NO release progressively declined with the increase in BMI. No association was found between HDL function and PM exposure, but a modifying effect of BMI was observed. The positive association between PM10 exposure at day −1 and NO production found at normal BMI values was lost in participants with higher BMI. Similar results were obtained for the reduction in macrophage cholesterol. The loss of the compensatory response of HDL function to PM exposure at increasing BMI levels could contribute to the endothelial dysfunction induced by PM and help to explain the susceptibility of subjects with obesity to air pollution.

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Joint effect of multiple air pollutants on lipid profiles in obese and normal-weight young adults: The key role of ozone

Cited by 15 publications

References 49 publications

Association between exposure to air pollution and blood lipids in the general population of Spain

Association between exposure to air pollution and blood lipids in the general population of Spain

Urban heat: an increasing threat to global health

Body Mass Index Modulates the Impact of Short-Term Exposure to Air Particulate Matter on High-Density Lipoprotein Function

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