Joint Effect of Obesity and Teenage Pregnancy on the Risk of Preeclampsia: A Population-Based Study

Effect of age, parity, and race on the incidence of pregnancy associated hypertension and eclampsia in the United States

“…3 Gestational hypertension and preeclampsia have similar risk factors and are precursors of insulin resistance and future cardiovascular disease [15,[17][18][19][20][21]. There are conflicting reports about the risk of preeclampsia in adolescents compared with young adults, in part because most studies lack information about parity or lack sufficient statistical power [1,2,9]. A systematic review of controlled studies about the effect of age concluded that women aged >40 years have a 2-fold increased risk of developing preeclampsia, and no adverse risk was noted in pregnancies in adolescents [2].…”

“…A randomized cohort study that used the National Hospital Discharge Survey in the United States reported a decreasing risk of preeclampsia with increased age in adolescence, but the results were not stratified by parity [1]. A randomized cohort study using data from the State of Florida Bureau of Vital Statistics noted an age-related decreasing trend in the incidence pattern in adolescence for preeclampsia [9]. Although the study also did not stratify by parity, parity was considered in a logistic regression model to adjust the incidence results [9].…”

“…A randomized cohort study using data from the State of Florida Bureau of Vital Statistics noted an age-related decreasing trend in the incidence pattern in adolescence for preeclampsia [9]. Although the study also did not stratify by parity, parity was considered in a logistic regression model to adjust the incidence results [9]. Neither study excluded women with preexisting hypertension [1,9].…”

“…Although the study also did not stratify by parity, parity was considered in a logistic regression model to adjust the incidence results [9]. Neither study excluded women with preexisting hypertension [1,9].…”

“…However, there is controversy about the relation between young maternal age and gestational hypertensive disorders. Most studies were limited because of insufficient sample size, were not stratified by parity, or did not exclude subjects with pregestational hypertension [1,2,9].…”