Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor α, interleukin 1, and receptor activator of nuclear factor κB ligand (RANKL) regulate osteoclasts

Ireland, Deborah C.; Bord, S.; Je, Compston

doi:10.1136/ard.2003.008458

Cited by 104 publications

(73 citation statements)

References 38 publications

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“…This is consistent with previous observations indicating a cooperation of cytokines in inflammation-mediated osteoclastogenesis (12,14,16). A low-level constitutive RANKL seems to be mandatory for osteoclastogenesis to take place, as indicated by experiments with RANKLknockout mice (45), and the effect of even trace amounts of RANKL is potentiated by proinflammatory cytokines (46).…”

Section: Discussionsupporting

confidence: 82%

“…In addition, several proinflammatory cytokines induce multinucleation of osteoclast precursors and/or commitment to the osteoclast phenotype (TNF␣, interleukin-1␤ [IL-1␤], IL-15, and IL-17 [12][13][14][15][16]) and may act synergistically with RANKL. In fact, the macrophage can serve both as osteoclast progenitor and as a source of osteoclastogenic cytokines (17,18).…”

Section: Methods T Cells and Monocytes Were Isolatedmentioning

confidence: 99%

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Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin‐15 on the cell surface and promote osteoclastogenesis in autologous monocytes

Miranda-Carús

Benito-Miguel

Balsa

et al. 2006

Arthritis & Rheumatism

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Section: Discussionsupporting

confidence: 82%

Section: Methods T Cells and Monocytes Were Isolatedmentioning

confidence: 99%

Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin‐15 on the cell surface and promote osteoclastogenesis in autologous monocytes

Miranda-Carús

Benito-Miguel

Balsa

et al. 2006

Arthritis & Rheumatism

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“…Activated T cells and RA synovial fibroblasts express RANKL and have the capacity to induce osteoclast differentiation (4,5). Several proinflammatory cytokines, such as TNF-␣, IL-1␤, IL-15, and IL-17, induce the multinucleation of osteoclast precursors or their commitment to the osteoclast phenotype and may act synergistically with RANKL (6).…”

mentioning

confidence: 99%

IL-23 Induces Receptor Activator of NF-κB Ligand Expression on CD4+ T Cells and Promotes Osteoclastogenesis in an Autoimmune Arthritis Model

Cho

Moon

et al. 2008

The Journal of Immunology

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IL-23, a clinically novel cytokine, targets CD4+ T cells. Recent IL-1Ra−/− mouse studies have demonstrated that IL-23 indirectly stimulates the differentiation of osteoclast precursors by enhancing IL-17 release from CD4+ T cells. IL-17, in turn, stimulates osteoclastogenesis in osteoclast precursor cells. In this study, we found that IL-23 up-regulates receptor activator of NF-κB ligand expression by CD4+ T cells, and thus contributes to osteoclastogenesis. This indirect pathway is mediated by NF-κB and STAT3. We have also demonstrated that IL-23 can influence osteoclastogenesis positively under the special conditions in the IL-1-dominant milieu of IL-1Ra−/− mice. We propose that IL-23-enhanced osteoclastogenesis is mediated mainly by CD4+ T cells. The results of this study show that IL-23 is a promising therapeutic target for the treatment of arthritis-associated bone destruction.

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“…In addition, IL-1β is a cytokine that induces IL-6, IL-8, prostaglandin E2, and other inflammatory mediators 27) . Both cytokines are produced in large amounts in response to bacterial or viral infection [28][29][30] , and they stimulate the differentiation and bone-resorbing activities of anaplastic osteoclastic cells 31) . Therefore, investigating the effects of dental materials on cytokine production can help predict their effects on mucous membranes.…”

Section: Discussionmentioning

confidence: 99%

Cytocompatibility of a Tissue Conditioner Containing Vinyl Ester as a Plasticizer

et al. 2007

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In the current study, we examined the cytocompatibility of eight vinyl esters as candidate plasticizers for producing phthalate-and ethanol-free tissue conditioners. We measured the estrogenic activity and cytotoxicity of vinyl esters in human fibroblasts and keratinocytes using an E-screen assay and a mitochondrial dye conversion assay, respectively. We also assessed the cytotoxicity of three prototype materials and commercially available tissue conditioners on human fibroblasts grown in collagen gels. Finally, we measured the effects of these materials on the expression of cytokines in three-dimensional cultures by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assays. None of the tested vinyl esters had estrogenic activity. Vinyl octanoate and vinyl pivalate were the least cytotoxic of the eight tested vinyl esters. In the same vein, a prototype tissue conditioner containing vinyl octanoate had equivalent or weaker cytotoxicity and induction of cytokine expression than conventional materials.

show abstract

Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor α, interleukin 1, and receptor activator of nuclear factor κB ligand (RANKL) regulate osteoclasts

Cited by 104 publications

References 38 publications

Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin‐15 on the cell surface and promote osteoclastogenesis in autologous monocytes

Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin‐15 on the cell surface and promote osteoclastogenesis in autologous monocytes

IL-23 Induces Receptor Activator of NF-κB Ligand Expression on CD4+ T Cells and Promotes Osteoclastogenesis in an Autoimmune Arthritis Model

Cytocompatibility of a Tissue Conditioner Containing Vinyl Ester as a Plasticizer

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