Joint fatigue-failure: A demonstration of viscoelastic responses to rate and frequency loading parameters using the porcine cervical spine

Zehr, Jackie D.; Buchman-Pearle, Jessa M.

doi:10.1016/j.jbiomech.2020.110081

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…Spinal tissues and mechanical responses were assumed to be elastic and time-independent (Khalaf and Nikkhoo, 2021; Zehr et al, 2020; Zheng et al, 2022); nevertheless, we simulated intervertebral disc as an incompressible elastic material which could accurately represent the short-term response of a poroelastic model (Ateshian et al, 2006; Ghezelbash et al, 2022; Shirazi et al, 2008). The scaling algorithm took account of geometric changes in the passive spine as well as the muscle architecture; however, we did not adjust changes in the intrinsic material properties with model inputs (as expected in general population and also with ageing and disc degeneration) because of the complexity of the issue as well as the paucity of the data in the literature.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a subject-specific integrated finite element musculoskeletal model of human trunk with ergonomic and clinical applications

Ghezelbash,

Eskandari,

Shirazi-Adl

et al. 2024

Preprint

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Background and Objectives: Biomechanical modeling of the human trunk is crucial for understanding spinal mechanics and its role in ergonomics and clinical interventions. Traditional models have been limited by only considering the passive structures of the spine in finite element (FE) models or incorporating active muscular components in multi-body musculoskeletal (MS) models with an oversimplified spine. This study aimed to develop and validate a subject-specific coupled FE-MS model of the trunk that integrates detailed representation of both the passive and active components for biomechanical simulations. Methods: We constructed a parametric FE model of the trunk, incorporating a realistic muscle architecture, personalized through imaging datasets and statistical shape models. To validate the model, we compared tissue-level responses with in vitro experiments, and muscle activities and intradiscal pressures versus in vivo measurements during various physical activities. We further demonstrated the versatility of the proposed personalized integrated framework through additional applications in ergonomics (i.e., wearing an exoskeleton) and surgical interventions (e.g., nucleotomy and spinal fusion). Results: The model demonstrated satisfactory agreement with experimental data, showcasing its validity to predict tissue- and disc-level responses accurately, as well as muscle activity and intradiscal pressures. When simulating ergonomics scenarios, the exoskeleton-wearing condition resulted in lower intradiscal pressures (1.9 MPa vs. 2.2 MPa at L4-L5) and peak von Mises stresses in the annulus fibrosus (2.2 MPa vs. 2.9 MPa) during forward flexion. In the context of surgical interventions, spinal fusion at L4-L5 led to increased intradiscal pressure in the adjacent upper disc (1.72 MPa vs. 1.58 MPa), whereas nucleotomy minimally influenced intact disc pressures but significantly altered facet joint loads and annulus fibrosus radial strains. Conclusions: The integrated FE-MS model of the trunk represents a significant advancement in biomechanical simulations, providing insights into the intricate interplay between active and passive spinal components. Its predictive capability extends beyond that of conventional models, enabling detailed risk analysis and the simulation of varied surgical outcomes. This comprehensive tool has potential implications for the design of ergonomic interventions and the optimization of surgical techniques to minimize detrimental effects on spinal mechanics.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a subject-specific integrated finite element musculoskeletal model of human trunk with ergonomic and clinical applications

Ghezelbash,

Eskandari,

Shirazi-Adl

et al. 2024

Preprint

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“…Cyclic compression groups differed by posture (neutral and flexed), loading duration (1000, 3000, 5000 cycles), and variation of peak compression force about a normalized mean of 30% UCT (10%, 20%, 40%). A maximum loading duration of 5000 cycles was selected to approximate 94% of the FSUs cyclic loading life span for the given compression force and frequency parameters 26. Compression-time waveforms were obtained from in vivo lifting data and the normalized compression magnitudes (30% UCT) approximated a low-moderate demand lifting task 27–30.…”

Section: Methodsmentioning

confidence: 99%

“…A maximum loading duration of 5000 cycles was selected to approximate 94% of the FSUs cyclic loading life span for the given compression force and frequency parameters. 26 Compression-time waveforms were obtained from in vivo lifting data and the normalized compression magnitudes (30% UCT) approximated a low-moderate demand lifting task. [27][28][29][30] All compression waveforms had a loading frequency of 1 Hz and were applied in force control.…”

Section: Loading Proceduresmentioning

confidence: 99%

Incidence of Compression-Induced Microinjuries in the Cartilage Endplate of the Spine

Zehr

Quadrilatero

Callaghan

2022

Spine

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Study Design. In vitro biomechanical study. Objective. This study investigated the incidence of microstructural endplate injuries caused by cyclic compression loading. The covarying effects of joint posture, loading duration, and peak compression variation were assessed. Summary of Background Data. The endplate is physiologically and functionally important for the maintenance of spine health. Despite the ability to radiographically diagnose and classify macroscopic endplate injuries, the mechanical mechanisms of injury initiation and progression remain largely unknown. Methods. One hundred and fourteen porcine cervical spinal units were examined. All spinal units were exposed to preconditioning tests, followed by cyclic compression testing that differed by posture (flexed, neutral), loading duration (1000, 3000, 5000 cycles), and peak compression variation (10%, 20%, 40%). Microstructural injuries were examined via immunofluorescence staining for collagen I (i.e., subchondral bone) and collagen II (i.e., hyaline cartilage endplate). From the 678 acquired images, the incidence of node, avulsion, cartilage, and circumferential pore microinjuries were determined. The distribution of microinjuries between postures, spinal levels, and vertebrae were evaluated along with the associations of incidence and size of injuries with loading duration and variation. Results. The incidence of avulsion injuries was significantly greater in caudal endplates (92%, P=0.006). No other injuries differed between vertebrae (P≥0.804) and no significant differences were observed between spinal units (P≥0.158). With respect to posture, 100% (P<0.001) and 90% (P<0.001) of avulsion and node injuries, respectively, occurred in flexed postures, whereas 82% (P<0.001) of cartilage microinjuries occurred with neutral postures. Loading duration was significantly associated with microinjury incidence (P<0.001) and lesion size (P≤0.003). Conclusion. Mechanical factors such as posture did not appreciably affect the incidence of endplate injury, but microinjury types were differently distributed between flexed and neutral postures. The duration of compression was shown to have an important role in the incidence of microinjury and lesion size.

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Mechanically induced histochemical and structural damage in the annulus fibrosus and cartilaginous endplate: a multi-colour immunofluorescence analysis

et al. 2022

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Joint fatigue-failure: A demonstration of viscoelastic responses to rate and frequency loading parameters using the porcine cervical spine

Cited by 11 publications

References 41 publications

Development and validation of a subject-specific integrated finite element musculoskeletal model of human trunk with ergonomic and clinical applications

Development and validation of a subject-specific integrated finite element musculoskeletal model of human trunk with ergonomic and clinical applications

Incidence of Compression-Induced Microinjuries in the Cartilage Endplate of the Spine

Mechanically induced histochemical and structural damage in the annulus fibrosus and cartilaginous endplate: a multi-colour immunofluorescence analysis

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