O steoarthritis (OA) is a significant health prob lem worldwide, affect ing approximately 10% of men and 18% of women over 60 years of age. 73 OA typically affects weight-bearing joints, is historically diagnosed later in life, and is a major cause of morbidity, disability, and pain. 20,36 The onset of OA increases with age, and up to half of people over 50 years of age report symptomatic OA.35 Some physical risk factors may also be associated with an increased rate of early onset of OA and require further investigation. For example, longitudinal studies provide evidence of a significantly increased risk of knee OA 12 to 20 years post-knee injury (ie, meniscus or anterior cruciate ligament injury). 61 In addition, there is evidence that knee and ankle injuries, T T STUDY DESIGN: Systematic review with metaanalysis.
T T OBJECTIVES:To identify risk factors for osteoarthritis (OA) of the knee, hip, and ankle, including joint injury, sport, physical activity, overweight/obesity, and occupational activity, in all age groups.
T T BACKGROUND:OA is a significant health problem worldwide, affecting up to 10% of men and 18% of women over 60 years of age. There has not been a comprehensive review examining modifiable physical risk factors associated with the onset of OA. This evidence is important to inform the physiotherapy management of individuals following onset of OA.
T T METHODS:Twelve electronic databases were systematically reviewed. The studies selected met the following criteria: (1) original data; (2) joint injury, sport activity, physical activity, overweight/ obesity, and/or occupational activity investigated as risk factors; (3) outcomes included OA (hip, knee, and/or ankle); and (4) analytic component of study design. The data extracted included study design, years of follow-up, study population, OA definition, risk factors, and results (effect estimates reported or calculated where available). The quality of evidence was assessed based on a modified version of the Downs and Black checklist.
T T RESULTS:Joint injury, obesity, and occupational activity were associated with an increased risk of OA of the knee and hip. Sport and physical activity produced inconsistent findings. Joint injury was identified as a significant risk factor for knee OA (combined odds ratio = 3.8; 95% confidence interval: 2.0, 7.2) and hip OA (combined odds ratio = 5.0; 95% confidence interval: 1.4, 18.2), as was previous meniscectomy with or without anterior cruciate ligament injury for knee OA (combined odds ratio = 7.4; 95% confidence interval: 4.0, 13.7). There is a paucity of research examining risk factors associated with ankle OA; this review identified only 2 studies with this outcome.
T T CONCLUSION:Joint injury, obesity, and occupational activity are associated with an increased risk of knee and hip OA. Some findings remain inconclusive, including levels of physical activity and sport specificity in individuals who do not suffer an injury. Early identification of individuals at risk for OA provides an opportunity for physiot...