2006
DOI: 10.1016/j.clindermatol.2006.07.013
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Joint hypermobility and skin elasticity: the hereditary disorders of connective tissue

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Cited by 98 publications
(69 citation statements)
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References 86 publications
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“…Ehlers-Danlos is a familial, transmissible pathology of connective tissue, resulting from defective protein synthesis [32]. These alterations are responsible for numerous clinical manifestations (e.g., pain, joint disorders, fatigue, skin fragility, haemorrhages, digestive problems, ENT problems, respiratory problems, dysautonomia, dystonia, bladder and sphincter problems, oral and dental problems, and cognitive disturbances).…”
Section: Resultsmentioning
confidence: 99%
“…Ehlers-Danlos is a familial, transmissible pathology of connective tissue, resulting from defective protein synthesis [32]. These alterations are responsible for numerous clinical manifestations (e.g., pain, joint disorders, fatigue, skin fragility, haemorrhages, digestive problems, ENT problems, respiratory problems, dysautonomia, dystonia, bladder and sphincter problems, oral and dental problems, and cognitive disturbances).…”
Section: Resultsmentioning
confidence: 99%
“…Manobras do sistema Beighton: hiperextensão do quinto dedo igual ou maior que 90º, hiperextensão do cotovelo maior que 10º, hiperextensão do joelho maior que 10º, a posição do polegar para a face flexora do antebraço e flexão anterior do tronco com apoio das duas mãos no chão com joelhos estendidos 3 . O diagnóstico da HA refere-se a um escore maior ou igual a quatro pontos.…”
Section: Diagnóstico Da Hipermobilidade Articularunclassified
“…Na HA, o feedback proprioceptivo e sensorial está diminuído e o posicionamento espacial alterado da articulação levam a maior frequência de ativação e deformação dos mecanorreceptores nos músculos e na pele 2 . A principal causa da hipermobilidade é uma anormalidade na síntese de proteína do colágeno, resultando em tecido conjuntivo enfraquecido e distensível 3 . A frouxidão ligamentar predispõe à HA, subluxações, deslocamentos ocasionando alterações biomecânicas nas articulações 3,4 Os mecanorreceptores convertem a energia mecânica da deformação física em potenciais de ação nervosos levando a um aumento na descarga aferente.…”
Section: Introductionunclassified
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“…1 According to the most recent classification standards, EDS consists of 6 main subtypes with the hypermobility type (EDS-HT) being considered the most common subtype 2 (Table 1). Although there have been no systematic epidemiological studies examining the true incidence of EDS-HT, it has been proposed that EDS-HT has a frequency of 0.75-2% 3 and is known to be more common among nonwhite populations and women. 4 Like in other EDS subtypes, EDS-HT is thought to be caused by mutations in gene encoding collagen chains but molecular based studies have yet to prove this theory true and as a result the etiology of EDS-HT remains unknown.…”
Section: Introductionmentioning
confidence: 99%