Joint image reconstruction algorithm in Compton cameras

Röser, J.; Barrientos, L.; Alberola, José Bernabéu; Borja-Lloret, Marina; Muñoz, Enrique; Ros, Alberto; Viegas, Rita; Llosá, G.

doi:10.1088/1361-6560/ac7b08

Cited by 8 publications

(2 citation statements)

References 51 publications

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“…The flexibility introduced by the dynamic dual-FOV SCE collimator allows the user to carry out joint image reconstructions using the projections acquired with both the wide-FOV and in the HR-HS configuration. Joint image reconstruction methods have been recently explored for Compton imaging (Roser et al 2022 ) and in several SPECT imaging applications, such as ictal/interictal SPECT imaging (Rakvongthai et al 2017 ), rest/stress myocardial perfusion SPECT (Lai et al 2018 ) and Y-90 Bremsstrahlung SPECT (Chun et al 2020 ), consistently showing an improvement in the imaging performance and quantitation.…”

Section: Methodsmentioning

confidence: 99%

Design and development of the DE-SPECT system: a clinical SPECT system for broadband multi-isotope imaging of peripheral vascular disease

Zannoni,

Sankar,

Jin

et al. 2024

Phys. Med. Biol.

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Objective Peripheral Vascular Disease (PVD) affects more than 230 million people worldwide and is one of the leading causes of disability among people over age 60. Nowadays, PVD remains largely underdiagnosed and undertreated, and requires the development of tailored diagnostic approaches. We present the full design of the Dynamic Extremity SPECT (DE-SPECT) system, the first organ-dedicated SPECT system for lower extremity imaging, based on 1-cm thick Cadmium Zinc Telluride (CZT) spectrometers and a dynamic dual field-of-view (FOV) synthetic compound-eye collimator. ApproachThe proposed DE-SPECT detection system consists of 48 1-cm thick 3D-position-sensitive CZT spectrometers arranged in a partial ring of 59 cm in diameter in a checkerboard pattern. The detection system is coupled with a compact dynamic synthetic compound-eye (SCE) collimator that allows the user to select between two different FOVs at any time during an imaging study: a wide-FOV (28-cm diameter) configuration for dual-leg or scout imaging or a high-resolution and high-sensitivity (HR-HS) FOV (16-cm diameter) for single-leg or focused imaging. Main ResultsThe preliminary experimental data show that the CZT spectrometer achieves a 3D intrinsic spatial resolution of <0.75 mm FWHM and an excellent energy resolution over a broad energy range (2.6 keV FWHM at 218 keV, 3.3 keV at 440 keV). From simulations, the wide-FOV configuration offers a 0.034% averaged sensitivity at 140 keV and <8 mm spatial resolution, whereas the HR-HS configuration presents a peak central sensitivity of 0.07% at 140 keV and a ~5 mm spatial resolution. The dynamic SCE collimator enables the capability to perform joint reconstructions that would ensure an overall improvement in imaging performance.SignificanceThe DE-SPECT system is a stationary and high-performance SPECT system that offers an excellent spectroscopic performance with a unique computer-controlled dual-FOV imaging capability, and a relatively high sensitivity for multi-tracer and multi-functional SPECT imaging of the extremities.

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Section: Methodsmentioning

confidence: 99%

Design and development of the DE-SPECT system: a clinical SPECT system for broadband multi-isotope imaging of peripheral vascular disease

Zannoni,

Sankar,

Jin

et al. 2024

Phys. Med. Biol.

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“…This idea was first exploited for a Compton-PET system (see [102] and Sect. 4) and was recently adapted to multi-scatterer Compton camera to take into account the various detector planes and their different sensitivities [103].…”

Section: Image Reconstructionmentioning

confidence: 99%

Hybrid PET/Compton-camera imaging: an imager for the next generation

Llosá

Rafecas

2023

Eur. Phys. J. Plus

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Compton cameras can offer advantages over gamma cameras for some applications, since they are well suited for multitracer imaging and for imaging high-energy radiotracers, such as those employed in radionuclide therapy. While in conventional clinical settings state-of-the-art Compton cameras cannot compete with well-established methods such as PET and SPECT, there are specific scenarios in which they can constitute an advantageous alternative. The combination of PET and Compton imaging can benefit from the improved resolution and sensitivity of current PET technology and, at the same time, overcome PET limitations in the use of multiple radiotracers. Such a system can provide simultaneous assessment of different radiotracers under identical conditions and reduce errors associated with physical factors that can change between acquisitions. Advances are being made both in instrumentation developments combining PET and Compton cameras for multimodal or three-gamma imaging systems, and in image reconstruction, addressing the challenges imposed by the combination of the two modalities or the new techniques. This review article summarizes the advances made in Compton cameras for medical imaging and their combination with PET.

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A stochastic alternative technique for Compton Maximum Likelihood Expectation-Maximization (MLEM) reconstruction

Tomazinaki,

Stiliaris

2023

Computers in Biology and Medicine

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Joint image reconstruction algorithm in Compton cameras

Cited by 8 publications

References 51 publications

Design and development of the DE-SPECT system: a clinical SPECT system for broadband multi-isotope imaging of peripheral vascular disease

Design and development of the DE-SPECT system: a clinical SPECT system for broadband multi-isotope imaging of peripheral vascular disease

Hybrid PET/Compton-camera imaging: an imager for the next generation

A stochastic alternative technique for Compton Maximum Likelihood Expectation-Maximization (MLEM) reconstruction

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