Joint index vector: a novel assessment measure for stratified medicine in patients with rheumatoid arthritis

Nishiyama, Susumu; Sawada, Tetsuji; Nishino, Jinju; Tohma, Shigeto

doi:10.1186/s40537-018-0148-1

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Therefore, this study aimed to investigate the shift in PGA‐PhGA discordance and to identify the clinical features that are predictive of future positive discordance between PGA and PhGA using a nationwide Japanese RA database—the National Database of Rheumatic Diseases in Japan ( NinJa ) 20 . For clinical variables, this study included the joint indices (JIs) proposed by Nishiyama ( x , y , and z ), which are novel assessment measures for RA with 3 components: x and y are indices of RA disease activity in the upper and lower extremities, respectively, and z is an index of the predominance of large joint involvement 21,22 …”

Section: Introductionmentioning

confidence: 99%

“…20 For clinical variables, this study included the joint indices (JIs) proposed by Nishiyama (x, y, and z), which are novel assessment measures for RA with 3 components: x and y are indices of RA disease activity in the upper and lower extremities, respectively, and z is an index of the predominance of large joint involvement. 21,22 2 | ME THODS…”

Section: Introductionmentioning

confidence: 99%

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Clinical variables, including novel joint index, associated with future patient‐physician discordance in global assessment of rheumatoid arthritis (RA) disease activity based on a large RA database in Japan

et al. 2022

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Background: Discordance between patient global assessment (PGA) and physician global assessment (PhGA) of rheumatoid arthritis (RA) disease activity is mainly determined by pain and functional disabilities. This study aimed to investigate the shift in PGA-PhGA discordance and the variables associated with future positive discordance (PGA > PhGA) based on the NinJa database in Japan. Methods:We examined 7557 adults with RA registered in both NinJa 2014 and 2018, with a discordance cutoff of 3 on a 10-cm scale. The affected joint distribution was investigated using the joint indices x, y, and z, which were calculated as indices for the upper joint, lower joint, and large joint involvement, respectively. The variables in NinJa 2014 that were associated with positive discordance in NinJa 2018 were examined using binary stepwise logistic regression analysis.Results: Due to the small number of patients with RA categorized as having negative discordance (PGA < PhGA), we focused on patients with RA categorized as having either concordance or positive discordance. Logistic regression analysis revealed that positive discordance in NinJa 2018 was associated with age, pain, modified Health Assessment Questionnaire (mHAQ) score, corticosteroid use, and existent positive discordance and was inversely associated with C-reactive protein (CRP) and x at baseline (NinJa 2014). The same findings were observed when patients with RA were divided based on the discordance status at baseline. Persistence (positive discordance to positive discordance) was associated with pain and mHAQ scores but inversely associated with CRP.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical variables, including novel joint index, associated with future patient‐physician discordance in global assessment of rheumatoid arthritis (RA) disease activity based on a large RA database in Japan

et al. 2022

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“…Nishiyama’s joint indices (JIs; x , y , z ) are novel measures for RA that consist of the following three components: x and y are indices of RA disease activity in the upper and lower extremities, respectively, while z is an index reflecting the predominance of large-joint involvement [ 16 , 17 ]. The present study aimed to examine the frequency of DIP joint involvement in patients with RA, and to determine its relationship with RA disease activity and affected joint distribution, based on data obtained from the National Database of Rheumatic Diseases in Japan ( NinJa ) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Distal Interphalangeal Joint Involvement May Be Associated with Disease Activity and Affected Joint Distribution in Rheumatoid Arthritis

Mizuuchi

Sawada

Nishiyama

et al. 2022

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We investigated the relationship between distal interphalangeal (DIP) joint involvement and disease activity in 10,038 patients with adult-onset rheumatoid arthritis (RA). The affected joint distribution was investigated using the joint indices (JI) x, y, and z, corresponding to the upper and lower joints, and the predominance of large-joint involvement, respectively. DIP joint involvement (defined by the presence of tenderness and/or swelling in DIP joints) was present in 206 (2.1%) of 10,038 patients with RA. Patients with RA exhibiting DIP joint involvement were significantly younger, and more frequently women. DIP joint involvement was positively associated with Disease Activity Score-28 using C-reactive protein, and clinical variables related to high RA disease activity, including JIs x and y, and was negatively associated with JI z. JI x was significantly higher than JI y in RA patients with DIP joint involvement. An odds ratio analysis revealed that small-to-medium sized and upper-extremity joints ranked first, second, and fourth among the eight variables significantly associated with DIP joint involvement. The correlation coefficients revealed that small-sized and upper-extremity joints ranked first and second among the five significant variables. DIP joint involvement, albeit rare, is significantly associated with high RA disease activity with predominance of small-sized and upper-extremity joints.

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Joint index vector: a novel assessment measure for stratified medicine in patients with rheumatoid arthritis

Cited by 2 publications

References 15 publications

Clinical variables, including novel joint index, associated with future patient‐physician discordance in global assessment of rheumatoid arthritis (RA) disease activity based on a large RA database in Japan

Clinical variables, including novel joint index, associated with future patient‐physician discordance in global assessment of rheumatoid arthritis (RA) disease activity based on a large RA database in Japan

Distal Interphalangeal Joint Involvement May Be Associated with Disease Activity and Affected Joint Distribution in Rheumatoid Arthritis

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