Joint Injury and Post-Traumatic Arthritis

Olson, Steven A.; Furman, Bridgette D.; Guilak, Farshid

doi:10.1007/s11420-011-9247-7

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…Rate of primary healing, healing time, incidence of talus necrosis, incidence of post-traumatic arthritis, functional outcomes, and any possible complications were recorded. Post-traumatic arthritis was considered to be achieved if there exists narrowing joint space, subchondral bone sclerosis, osteophyte formation and bone cystic degeneration [ 23 ]. The incidence of post-traumatic arthritis of the ankle was determined using imaging data by a senior author (ZG Zhang).…”

Section: Methodsmentioning

confidence: 99%

The application of intraoperative ankle dislocation approach in the treatment of the unstable trimalleolar fractures involving posterior ankle comminuted fracture: a retrospective cohort study

Xie

Wang

et al. 2018

BMC Surg

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BackgroundThe aim of this study was to introduce a novel intraoperative lateral ankle dislocation approach during surgical treatment for patients with unstable trimalleolar fractures involving posterior ankle comminuted fractures and compare its effects and safety with those with conventional approach.MethodsFrom June 2006 to June 2014, 69 patients diagnosed as unstable trimalleolar fractures involving posterior ankle comminuted fracture were included in this study. The patients were divided into intraoperative dislocating ankle group (experimental group) and conventional treatment group (control group) according to surgical modalities. The following parameters including rate of primary healing, healing time, incidence of talus necrosis, incidence of post-traumatic arthritis, functional outcomes according to Baird-Jackson classification system, and any possible complications in two groups were recorded and compared.ResultsThere were no significant differences regarding the rate of primary healing, healing time and the rate of talus necrosis in two groups (P > 0.05). The incidence of post-traumatic arthritis in experimental and control group were 0 and 24.24% (P = 0.0006), respectively. The rate of excellent and good outcomes were achieved in 91.67% in experimental group and 72.73% in control group (P = 0.038), respectively.ConclusionsThe findings suggest that the intraoperative ankle dislocation approach appears to be a promising surgical option for unstable trimalleolar fractures involving posterior ankle comminuted fracture because it can provide better functional outcomes and lower incidence of post-traumatic arthritis while not compromising primary healing and healing time.

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Section: Methodsmentioning

confidence: 99%

The application of intraoperative ankle dislocation approach in the treatment of the unstable trimalleolar fractures involving posterior ankle comminuted fracture: a retrospective cohort study

Xie

Wang

et al. 2018

BMC Surg

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Section: Pathogenic Mechanisms and Role Of Inflammation In Early Phasementioning

confidence: 99%

“…The initial pathological changes may vary depending on the severity of the tissue damage: low-intensity injuries commonly cause articular surface damages without bone fractures, which instead are displaced by high-intensity injuries. 32 The immediate cartilage swelling is caused by collagen rupture and rapid glycosaminoglycans (GAG) loss. Collagen damage is an irreversible step in the progression to PTOA, since the rapid loss of tensile behaviour of the tissue could not be restrained by the fibrillated collagen network.…”

Section: Pathogenic Mechanisms and Role Of Inflammation In Early Phasmentioning

confidence: 99%

Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation

et al. 2016

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Post-traumatic arthritis (PTA) develops after an acute direct trauma to the joints. PTA causes about 12% of all osteoarthritis cases, and a history of physical trauma may also be found in patients with chronic inflammatory arthritis. Symptoms include swelling, synovial effusion, pain and sometimes intra-articular bleeding. Usually, PTA recoveries spontaneously, but the persistence of symptoms after 6 months may be considered pathological and so-called chronic PTA. A variety of molecular, mechanobiological and cellular events involved in the pathogenesis and the progression of PTA have been identified. The activation of inflammatory mechanisms during the PTA acute phase appears to play a critical role in the chronic disease onset. Human studies and experimental models have revealed that a series of inflammatory mediators are released in synovial fluid immediately after the joint trauma. These molecules have been proposed as markers of disease and as a potential target for the development of specific and preventative interventions. Currently, chronic PTA cannot be prevented, although a large number of agents have been tested in preclinical studies. Given the relevance of inflammatory reaction, anticytokines therapy, in particular the inhibition of interleukin 1 (IL-1), seems to be the most promising strategy. At the present time, intra-articular injection of IL-1 receptor antagonist is the only anticytokine approach that has been used in a human study of PTA. Despite the fact that knowledge in this area has increased in the past years, the identification of more specific disease markers and new therapeutic opportunities are needed.

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“…The pathology of PTOA involves three phases: the immediate phase following mechanical injury; the acute phase displaying apoptosis and inflammation; and the chronic phase characterized by dysfunction and pain of the joint [ 10 ]. Biochemical changes occurring after trauma mainly depend on whether the impact is of low or high amplitude [ 11 ]. The most common irreversible biochemical change is the breakdown of the cartilage matrix due to a disruption of proteoglycans that expose the underlying collagens maintaining the stability of the cartilage matrix.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice

Bhatti

Jeong

et al. 2022

Antioxidants

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The pathophysiology of post-traumatic arthritis (PTOA) is not fully understood. This study used non-invasive repetitive mechanical loading (ML) mouse models to study biochemical, biomechanical, and pain-related behavioral changes induced in mice. Mouse models reflected the effects of the early stages of PTOA in humans. For the PTOA model, cyclic comprehensive loading (9N) was applied to each mouse’s left knee joint. ML-induced biochemical and molecular changes were analyzed after loading completion. Cartilage samples were examined using gene expression analysis. Tissue sections were used in subsequent OA severity scoring. Biomechanical features and pain-related behavior were studied after 24 h and three weeks post-ML sessions to examine the development of PTOA. The loaded left knee joint showed a greater ROS/RNS signal than the right knee, which was not loaded. There was a significant increase in cartilage damage and MMP activity in the mechanically loaded joints relative to non-loaded control knee joints. Similarly, we found a difference in the viscoelastic tangent, which highlights significant changes in mechanical properties. Biochemical analyses revealed significant increases in total NO, caspase-3 activity, H2O2, and PGE2 levels. Gene expression analysis highlighted increased catabolism (MMP-13, IL-1β, TNF-α) with a concomitant decrease in anabolism (ACAN, COL2A1). Histopathology scores clearly indicated increases in OA progression and synovitis. The gait pattern was significantly altered, suggesting signs of joint damage. This study showed that biomechanical, biochemical, and behavioral characteristics of the murine PTOA groups are significantly different from the control group. These results confirm that the current mouse model can be considered for translational PTOA studies.

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Joint Injury and Post-Traumatic Arthritis

Cited by 9 publications

References 19 publications

The application of intraoperative ankle dislocation approach in the treatment of the unstable trimalleolar fractures involving posterior ankle comminuted fracture: a retrospective cohort study

The application of intraoperative ankle dislocation approach in the treatment of the unstable trimalleolar fractures involving posterior ankle comminuted fracture: a retrospective cohort study

Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation

Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice

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