Joint Involvement Associated with Inflammatory Bowel Disease

Vos, Martine De

doi:10.1159/000233290

Cited by 25 publications

(7 citation statements)

References 50 publications

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“…Treatment of, for instance, arthritis often includes a short-term use of non-steroidal anti-inflammatory drugs (NSAID) [49]. Previous results from the present research program showed that IBS cases of both sexes consumed significantly more analgesics than their controls did [50]. Registered diagnoses of thyroid disease, asthma, allergy, infections in the urinary tract as well as cardiovascular problems were more frequent among the IBS cases.…”

Section: Discussionmentioning

confidence: 84%

Patients with irritable bowel syndrome are more burdened by co-morbidity and worry about serious diseases than healthy controls- eight years follow-up of IBS patients in primary care

et al. 2013

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BackgroundIrritable Bowel Syndrome (IBS) is a hidden public health disease that affects up to 20% of the general population. Although co-morbidity can affect diagnose setting and treatment of the disease, there are few studies concerning diagnosed and registered co-morbidity for IBS patients in primary care. The aim of this study was to analyse co-morbidity among IBS-patients compared to age- and sex-matched controls from the general population using data from a county-wide computerized medical record system.MethodsIBS cases were recruited from three Swedish primary health care centres during a five-years period and controls from the same corresponding geographical areas. Co-morbidity data for IBS-patients and morbidity data for controls were derived from a population-based Health Care Register (HCR) covering all diagnoses in primary as well as hospital care in the region. Odds Ratios with 95% confidence intervals for morbidity in gastro-intestinal and non-gastrointestinal diagnoses for cases with irritable bowel syndrome compared to controls were calculated separately for each gender and diagnosis.ResultsWe identified more co-morbidity among IBS patients of both sexes, compared to matched controls in the general population. Patients with IBS were particularly more worried about having a serious disease than their control group. The risk among male IBS-cases to get this latter diagnose was three times higher compared to the male controls.ConclusionsIn this population based case–control study, the analysis of diagnoses from the HCR revealed a broad spectrum of common co-morbidity and significantly more physician-recorded diagnoses among IBS-patients in comparisons to the control group.

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Section: Discussionmentioning

confidence: 84%

Patients with irritable bowel syndrome are more burdened by co-morbidity and worry about serious diseases than healthy controls- eight years follow-up of IBS patients in primary care

et al. 2013

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“…Joint inflammation often accompanies IBD in humans, and therefore a link between the two diseases has been suggested [42,43]. Though some mice seemed to have diarrhea chronically, most only showed signs transiently.…”

Section: Resultsmentioning

confidence: 99%

“…Although several case studies have been published about RA patients who developed IBD [73,74], IBD is not considered a typical extraarticular manifestation of RA [2,3]. In contrast, joint inflammation occurs in 20% of patients diagnosed with IBD, though it is classified as peripheral or axial spondyloarthritis [42,43] and is typically seronegative for RF and anticyclic citrullinated peptide antibodies [75,76]. …”

Section: Discussionmentioning

confidence: 99%

Characterization of a novel and spontaneous mouse model of inflammatory arthritis

et al. 2011

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IntroductionMouse models of rheumatoid arthritis (RA) have proven critical for identifying genetic and cellular mechanisms of the disease. Upon discovering mice in our breeding colony that had spontaneously developed inflamed joints reminiscent of RA, we established the novel IIJ (inherited inflamed joints) strain. The purpose of this study was to characterize the histopathological, clinical, genetic and immunological properties of the disease.MethodsTo begin the IIJ strain, an arthritic male mouse was crossed with SJL/J females. Inheritance of the phenotype was then tracked by intercrossing, backcrossing and outcrossing to other inbred strains. The histopathology of the joints and extraarticular organ systems was examined. Serum cytokines and immunoglobulins (Igs) were measured by ELISA and cytometric bead array. Transfer experiments tested whether disease could be mediated by serum alone. Finally, the cellular joint infiltrate and the composition of secondary lymphoid organs were examined by immunohistochemistry and flow cytometry.ResultsAfter nine generations of intercrossing, the total incidence of arthritis was 33% (304 of 932 mice), with females being affected more than males (38% vs. 28%; P < 0.001). Swelling, most notably in the large distal joints, typically became evident at an early age (mean age of 52 days). In addition to the joint pathology, which included bone and cartilage erosion, synovial hyperproliferation and a robust cellular infiltration of mostly Gr-1+ neutrophils, there was also evidence of systemic inflammation. IL-6 was elevated in the sera of recently arthritic mice, and extraarticular inflammation was observed histologically in multiple organs. Total serum Ig and IgG1 levels were significantly elevated in arthritic mice, and autoantibodies such as rheumatoid factor and Ig reactive to joint components (collagen type II and joint homogenate) were also detected. Nevertheless, serum failed to transfer disease. A high percentage of double-negative (CD4-CD8-) CD3+ TCRα/β+ T cells in the lymphoid organs of arthritic IIJ mice suggested significant disruption in the T-cell compartment.ConclusionsOverall, these data identify the IIJ strain as a new murine model of inflammatory, possibly autoimmune, arthritis. The IIJ strain is similar, both histologically and serologically, to RA and other murine models of autoimmune arthritis. It may prove particularly useful for understanding the female bias in autoimmune diseases.

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“…Transient spondyloarthritis occurs in 10-20% of patients with inflammatory bowel disease (IBD), usually during a flare of intestinal inflammation. 1 Current theories on the pathogenesis of IBD posit that inflammation results from an inappropriate immune response to gut bacteria in genetically predisposed individuals. Advances in metagenomic analysis of the gut microbiota have revealed that changes in the composition of the gut microbiota are commonly associated with IBD, although it remains unclear whether these changes are the cause or the result of intestinal inflammation.…”

Section: Out Of Joint: New Insights Into the Role Of Commensal Gut Bamentioning

confidence: 99%

Out of joint: new insights into the role of commensal gut bacteria in autoimmune arthritis

Kaetzel¹

2010

Mucosal Immunology

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Joint Involvement Associated with Inflammatory Bowel Disease

Cited by 25 publications

References 50 publications

Patients with irritable bowel syndrome are more burdened by co-morbidity and worry about serious diseases than healthy controls- eight years follow-up of IBS patients in primary care

Patients with irritable bowel syndrome are more burdened by co-morbidity and worry about serious diseases than healthy controls- eight years follow-up of IBS patients in primary care

Characterization of a novel and spontaneous mouse model of inflammatory arthritis

Out of joint: new insights into the role of commensal gut bacteria in autoimmune arthritis

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