Joint Laxity Leading to Osteoarthrosis

Scott, D L; Bird, H. A.; Wright, V.

doi:10.1093/rheumatology/18.3.167

Cited by 66 publications

(27 citation statements)

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“…Community studies have confirmed a positive association between knee OA and chondrocalcinosis 14. There is an increased incidence of calcium pyrophosphate dihydrate and basic calcium phosphate crystals in synovial fluid and cartilage from OA joints,15 and also local mechanical factors (including joint hypermobility16 and instability,17 joint motion,18 ligamentous laxity19 and joint damage from surgery20 21 and trauma22) are known to predispose to localised secondary deposition of calcium pyrophosphate dihydrate crystals in the context of joint damage. It is possible that OA results in changes in tissue factors, either an increase in promoters or a reduction in inhibitors of crystal nucleation and growth, which might predispose not just to calcium crystal but also to MSU crystal deposition.…”

Section: Discussionmentioning

confidence: 98%

Are joints affected by gout also affected by osteoarthritis?

Roddy

Zhang²,

Doherty³

2007

Annals of the Rheumatic Diseases

131

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Objectives: To determine whether joints affected by gout are also affected by osteoarthritis (OA). Methods: A postal questionnaire was sent to all adults aged over 30 years registered with two general practices. The questionnaire assessed a history of gout (doctor diagnosed, or episodes suggestive of acute crystal synovitis) and medication use. Patients who possibly had gout attended for clinical assessment to verify the diagnosis on clinical grounds and assess the distribution of joints affected by acute attacks of gout and OA. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were calculated between the history of an acute attack of gout and the presence of OA at an individual joint adjusted for age, gender, body mass index and prior diuretic use in a binary logistic regression model. Results: A total of 4249 completed questionnaires were returned (32%). From 359 attendees, 164 cases of gout were clinically confirmed. A highly significant association existed between the site of acute attacks of gout and the presence of OA (aOR 7.94; 95% CI 6.27, 10.05). Analysis at individual joint sites revealed a significant association at the first metatarsophalangeal joint (aOR 2.06; 95% CI 1.28, 3.30), mid-foot (aOR 2.85; 95% CI 1.34, 6.03), knee (aOR 3.07; 95% CI 1. 05, 8.96) and distal interphalangeal joints (aOR 12.67; 95% CI 1.46, 109.91). Conclusion: Acute attacks of gout at individual joint sites are associated with the presence of clinically assessed OA at that joint suggesting that OA may predispose to the localised deposition of monosodium urate crystals.

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Section: Discussionmentioning

confidence: 98%

Are joints affected by gout also affected by osteoarthritis?

Roddy

Zhang²,

Doherty³

2007

Annals of the Rheumatic Diseases

131

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“…8,49,52 Some authors 6,51 reported that up to 60% of individuals with HMS developed osteoarthritis (OA) as opposed to 30% of patients without HMS who were seen in a rheumatology clinic. Other researchers 53 found that 24% of patients with OA had HMS, as opposed to only 8% of patients seen for general medical conditions. An increased incidence of OA may be secondary to chronic or traumatic biomechanical abnormalities or proprioceptive deficits.…”

Section: Clinical Presentationmentioning

confidence: 90%

Hypermobility Syndrome

Russek

1999

Physical Therapy

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“…Alterations or a shift in AP translational and IE rotational motion (Blankenvoort et al, 1988) of the knee during dynamic activities could have profound effects on secondary restraints such as the medial meniscus. Clinical reports (Buckland-Wright et al, 2000;Daniel et al, 1994;Lohmander and Roos, 1994;Roos et al, 1995;Scott et al, 1979) of the presence of osteoarthritis of the knee in patients with ACL injury suggest that abnormal motion at the knee could be a cause of degenerative changes. Yet, increased passive clinical laxity based on quantitative measurement has not correlated with clinical outcome (Snyder Mackler et al, 1997).…”

Section: Introductionmentioning

confidence: 99%