Joint symptoms in patients on bupropion therapy

Ornetti, Paul; Disson-Dautriche, Anne; Müller, G.; Cherasse, Anne; Tavernier, C; Besancenot, J.-F.; Sgro, C; Maillefert, Jean-Françis

doi:10.1016/j.jbspin.2003.10.004

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…According to our results, we hypothesized that the reason of underestimation may be related to the delayed onset phenomenon of bupropion-induced urticaria. In addition, bupropion-induced urticaria seldom develops alone and is sometimes accompanied with other more serious allergic reactions, including angioedema[ 19 , 20 ], arthralgia[ 8 ], serum sickness-like reaction[ 7 , 9 - 11 ], or symptoms of anaphylaxis, which may indicate a medical emergency. Therefore, if medical personnel do not recognize the adverse drug reaction, then patients could be put at risk for more severe drug hazards.…”

Section: Discussionmentioning

confidence: 99%

Delayed Onset Urticaria in Depressive Patients with Bupropion Prescription: A Nationwide Population-Based Study

Liu

et al. 2013

PLoS ONE

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BackgroundBupropion, which is widely used in patients with depressive disorder, may cause allergic reactions. However, the real prevalence of these side effects may be overlooked and underreported due to the delayed onset phenomenon.ObjectiveThis study aimed to estimate the real incidence of bupropion-induced urticaria and clarify the delayed onset phenomenon.MethodsWe conducted a nationwide cohort study between 2000 and 2009 using Taiwan’s National Health Insurance Dataset. Among 65,988 patients with depressive disorders, we identified new users of bupropion with depressive disorders (bupropion cohort, n = 2,839) and matched them at a ratio of 1:4 regarding age and sex (non-bupropion matched cohort, n = 11,356). The risk of urticaria was compared between the two cohorts.ResultsThe risk of urticaria occurrence was higher in bupropion users than in matched controls within 4 weeks of starting the medication (risk ratio 1.81; 95% confidence interval 1.28–2.54; p = 0.001). The occurrence of urticaria in the bupropion cohort were more frequent on Days 15–28 than Day 1–14 (p = 0.002). Cox proportional hazards model showed that a history of urticaria was an independent risk factor for developing bupropion-induced urticaria.ConclusionsOf the antidepressants, bupropion may pose a higher risk of drug-induced urticaria, and this condition might be ignored due to the delayed onset phenomenon. Depressive patients with a history of urticaria are at higher risk of the adverse drug reaction. This study emphasizes the need for increased clinical awareness of this adverse outcome to bupropion use.

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Section: Discussionmentioning

confidence: 99%

Delayed Onset Urticaria in Depressive Patients with Bupropion Prescription: A Nationwide Population-Based Study

Liu

et al. 2013

PLoS ONE

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“…In our study, we have found four cases of adverse events related to the use of this adaptogen. We hypothesize that through the inhibition of CYP2B6, CYP2C9, CYP2C9, CYP2C19, and CYP3A4, Schisandra chinensis preparations increased the concentration and side effects of bupropion (thrombocytopenia ( Altintas et al, 2013 ) and generalized arthralgia ( Ornetti et al, 2004 )), amitriptyline (delirium ( King and Ashraf, 2018 )), and fluoxetine (dysuria ( Fluoxetine Side Effects, 2023 )).…”

Section: Discussionmentioning

confidence: 99%

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs

Siwek,

Woroń,

Wrzosek

et al. 2023

Front. Pharmacol.

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Aim: We aimed to systematically evaluate the prevalence and clinical characteristics of adverse events associated with the adaptogens and antidepressant drug interactions in a retrospective chart review.Methodology: A total of 1,816 reports of adverse events were evaluated. Cases were included in the analysis if the pharmacoepidemiological analysis showed the presence of a high probability of a causal relationship between an adaptogen and antidepressant interaction and the occurrence of adverse events. The following data were extracted from the reports: age, sex, antidepressant, plant products containing adaptogens, other concomitant medications, and clinical consequences of the interactions and their possible mechanisms.Results: Adaptogens were involved in 9% of adverse events associated with the concomitant use of antidepressants and other preparations. We identified 30 reports in which side effects presented a causal relationship with the use of antidepressants and adaptogens. Here, we present the list of adaptogens with the corresponding antidepressants and the side effects caused by their interactions: Withania somnifera: reboxetine (testicle pain and ejaculatory dysfunctions), sertraline (severe diarrhea), escitalopram (myalgia, epigastric pain, nausea, vomiting, restless legs syndrome, and severe cough), and paroxetine (generalized myalgia, ophthalmalgia, and ocular hypertension); Eleutherococcus senticosus: duloxetine (upper gastrointestinal bleeding), paroxetine (epistaxis), sertraline (vaginal hemorrhage), and agomelatine (irritability, agitation, headache, and dizziness); Schisandra chinensis: bupropion (arthralgia and thrombocytopenia), amitriptyline (delirium), and fluoxetine (dysuria); Tribulus terrestris: citalopram (generalized pruritus), escitalopram (galactorrhea), and trazodone (psoriasis relapse); Coptis chinensis: mianserin (arrhythmias), mirtazapine (edema of lower limbs and myalgia), and fluoxetine (gynecomastia); Cimicifuga racemosa: mianserin (restless legs syndrome), paroxetine (gynecomastia and mastalgia), and venlafaxine (hyponatremia); Bacopa monnieri: agomelatine (back pain and hyperhidrosis) and moclobemide (myocardial infarction); Gynostemma pentaphyllum: duloxetine (back pain); Cordyceps sinensis: sertraline (upper gastrointestinal bleeding); Lepidium meyenii: mianserin (restless legs syndrome); and Scutellaria baicalensis: bupropion (seizures).Conclusion: Clinicians should monitor the adverse events associated with the concomitant use of adaptogens and antidepressant drugs in patients with mental disorders. Aggregation of side effects and pharmacokinetic interactions (inhibition of CYP and p-glycoprotein) between those medicines may result in clinically significant adverse events.

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Current awareness: Pharmacoepidemiology and drug safety

2005

Pharmacoepidem. Drug Safe.

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Joint symptoms in patients on bupropion therapy

Cited by 6 publications

References 8 publications

Delayed Onset Urticaria in Depressive Patients with Bupropion Prescription: A Nationwide Population-Based Study

Delayed Onset Urticaria in Depressive Patients with Bupropion Prescription: A Nationwide Population-Based Study

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs

Current awareness: Pharmacoepidemiology and drug safety

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