Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats

Su, Hong; Zhou, Li; Kenston, Samuel Selorm Fiati; Shi, Hongbo; Wang, Yafei; Song, Xin; Gu, Yuanliang; Barber, Tabatha; Aldinger, Joni; Zou, Baobo; Ding, Min; Zhao, Jinshun; Lin, Xiaohui

doi:10.3390/ijerph14101164

Cited by 27 publications

(23 citation statements)

References 40 publications

(40 reference statements)

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“…As a major port city in China, Ningbo is known for the variety of aquatic products it offers. The health hazards of metal pollution through fish consumption have attracted wide attention in recent years [ 18 ]. As an important coastal economic district, Ningbo is one of the most industrialized cities in eastern China, however, few studies have been conducted to investigate the status of the metal pollution of this city.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Study on Metal Pollution of Ningbo in China

Zhou

Wang

et al. 2018

IJERPH

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Background: In order to search for effective control and prevention measures, the status of metal pollution in Ningbo, China was investigated. Methods: Nine of the most common contaminating metals including lead (Pb), cadmium (Cd), copper (Cu), iron (Fe), manganese (Mn), chromium (Cr), nickel (Ni), zinc (Zn), and mercury (Hg) in samples of vegetables, rice, soil, irrigation water, and human hair were detected using inductively coupled plasma-mass spectrometry (ICP-MS). Three different districts including industrial, suburban and rural areas in Ningbo were studied through a stratified random sample method. Results: (1) Among all of the detected vegetable samples, Cd exceeded the standard limit rates in industrial, suburban and rural areas as high as 43.9%, 27.5% and 5.0%, respectively; indicating the severity of Cd pollution in Ningbo. (2) The pollution index (PI) of Cd and Zn in soil (1.069, 1.584, respectively) suggests that soil is slightly polluted by Cd and Zn. Among all samples, metal contamination levels in soil were all relatively high. (3) A positive correlation was found between the concentrations of Pb, Cd and Cu in vegetables and soil; Pb, Cu, Cr and Ni in vegetables and irrigation water, as well as, Cu and Ni in rice and irrigation water; and, (4) Higher Pb and Cd concentrations were found in student scalp hair in both industrial and suburban areas compared to rural areas. (5) Hg and Pb that are found in human scalp hair may be more easily absorbed from food than any of the other metals. Conclusions: In general, certain harmful metal pollutions were detected in both industrial and suburban areas of Ningbo in China.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Study on Metal Pollution of Ningbo in China

Zhou

Wang

et al. 2018

IJERPH

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“…The combination of different heavy metals can have an added toxicity due to its additive effects. Lead is found to have a toxic effect in a very low dose [14] . There was significant alteration in the liver function of Cadmium treated mice attributed to the modification in the hepatic genes, lipid metabolism, oxidative phosphorylation and cell death cascade.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental animals have shown varied clinical symptoms with lead exposure, ranging from cognitive, behavioral, and learning abnormalities. [14] Cadmium exposure has been lined to some cancers [17] . Nickel compound exposure has been associated with hypersensitivities and nephrotoxicity [18] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Heavy Metals on the Activity Levels of Hepatic Enzymes in the Maternal and Embryonic Tissues of Viviparous Scorpion (H. fulvipes)

Rao¹,

Acharya²,

S³

et al. 2017

IJLSSR

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ABSTRACT-An experimental study was performed with viviparous animal Heterometrous fulvipes to access the cumulative effect of chronic heavy metals exposure on the activity levels of the enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Chronic heavy metal exposure resulted in variation in the enzymes levels with increase in AST and decreases in ALT, contributed to the stress induced by the heavy metals. These changes in enzymatic activity of the maternal and embryonic tissue of H. fulvipes under the influence of heavy metal, mercury and lead is suggestive of the specific impact of mercury and lead on the enzymatic pathway, prompting a further study to consolidate the finding in human study. It is pertinent that the heavy metal toxicity be well documented and appropriate precaution taken in mother and fetus to decrease its detrimental effects.

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“…There are reports 31,32 of decreased renal function, hepatic injuries and disturbance in the electrolyte balance of rats treated with a high dose of heavy metal mixture. The present work demonstrates a significant increase in relative weights of the spleen, and immune system-related organ.…”

Section: Fig 5: Changes In the Relative Spleen Weight (G / 100 G Bodmentioning

confidence: 99%

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2020

IJPSR

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Being exposed to a number of heavy metals in the environment, humans are suffering from various health problems. Cadmium and arsenic are both priority hazardous substances and carcinogens. Environmental co-exposure to these heavy metals is also an important consideration and most experiments with laboratory animals investigate only one heavy metal. In the present study albino rats were exposed to both the heavy metals alone and in combination in 5 groups and the 6 th group was of control. Animals were treated for 30 days and 60 days with the lower doses of NaAsO 2 (4.3 mg/ks b. wt.) in group B and CdCl 2 (2.6 mg/kg b. wt.) in group D and higher dose of NaAsO 2 (8.6 mg/ks b. wt.) in group C and CdCl 2 (5.2 mg/kg b. wt.) in group E. A combination dose of CdCl 2 (2.6 mg/kg b. wt.) and NaAsO 2 (4.3 mg/ks b. wt.) was given to another group F of experimental animals. In 30 days, intoxicated animal groups the weights of the kidney, brain and heart increased and a significant increase in liver and spleen occurred both by arsenic and cadmium. Although the high dose of arsenic decreased the relative heart weight but the combination dose showed a significant increase in weight of all the organs. In 60 days treated groups both the heavy metals showed a reduced effect on heart weight, but the increase was observed in the brain, liver and spleen and kidney weight while combination dose showed a significant increase in the relative weight of spleen and liver. Bodyweight gain was reduced in 60 days of treated groups. QUICK RESPONSE CODE

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Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats

Cited by 27 publications

References 40 publications

Epidemiological Study on Metal Pollution of Ningbo in China

Epidemiological Study on Metal Pollution of Ningbo in China

Effect of Heavy Metals on the Activity Levels of Hepatic Enzymes in the Maternal and Embryonic Tissues of Viviparous Scorpion (H. fulvipes)

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