Women are particularly underrepresented in journals of the highest scientific impact, with substantial consequences for their careers. While a large body of research has focused on the outcome and the process of peer review, fewer articles have explicitly focused on gendered submission behavior and the explanations for these differences. In our study of nearly five thousand active authors, we find that women are less likely to report having submitted papers and, when they have, to submit fewer manuscripts, on average, than men. Women were more likely to indicate that they did not submit their papers (in general and their subsequently most cited papers) toScience, Nature, orPNASbecause they were advised not to. In the aggregate, no statistically significant difference was observed between men and women in how they rated the quality of their work. Nevertheless, regardless of discipline, women were more likely than men to indicate that their “work was not ground-breaking or sufficiently novel”as a rationale for not submitting to one of the listed prestigious journals. Men were more likely than women to indicate that the “work would fit better in a more specialized journal.” We discuss the implications of these findings and interventions that can serve to mitigate the disparities caused by gendered differences in submission behavior.SignificancePublishing in high-impact scholarly journals has a significant effect on researchers’ careers. Our findings identify factors that affect submission toScience, Nature, and theProceedings of the National Academy of Sciences of the United States of America(PNAS) and explore whether there is a relationship between gender and desk rejections or submission rates. We found no relationship between gender and reported desk rejection and a relationship between gender and reported submissions. Women were more likely than men to indicate that their “work was not ground-breaking or sufficiently novel” for the listed prestigious journals and that they were advised against submitting to these venues. Men were more likely to indicate that the “work would fit better in a more specialized journal.”