Based on computerized and manual content analyses, we examined the theories, methods, topics, and authors’ backgrounds of the empirical articles revolving around politics and media published by Journalism & Mass Communication Quarterly (JMCQ) in its 100 years ( N = 424). The most common theories are agenda-setting, framing, and selective exposure, and quantitative methods prevail with single-country studies being more prevalent than comparative analyses. A considerable portion of research has focused on political news, particularly during campaigns. Male, U.S.-based authors dominate, but female-authored work has increased in the past decade. Challenges remain to make the research on politics and media in JMCQ more generalizable globally.