“…Poorly controlled diabetics are at increased risk of dehydration (due to hyperglycemic osmotic diuresis), heat illness (Kenny et al, 2010;Yardley et al, 2013), or hypothermia (impaired thermogenesis in hypoglycemia), and any peripheral vascular or peripheral neuropathic complications that increase the risk of cold injury or frostbite. Other comorbidities such as renal, coronary artery, or ocular disease add further hazard to altitude travel (Bartsch and Gibbs, 2007;Burtscher, 2007;Luks et al, 2008;Mader and Tabin, 2003;Mieske et al, 2010;Milledge and Kupper, 2008;Wu et al, 2007). Nevertheless, as the prevalence of diabetes is now 4.4% in the United Kingdom (HM Government UK 2009), 8.3% in the USA (American Diabetes Association 2011), and anticipated to affect 366 million worldwide by 2030 (Wild et al, 2004), diabetics inevitably travel to high destinations for business, or as tourists, skiers, trekkers, or mountaineers, and appear to cope reasonably well.…”