JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference

Babigian, Christopher J.; Giudice, Jimena; Wahlestedt, Claes; Sartor, Gregory C.

doi:10.1016/j.bbr.2021.113644

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…Targeting BET proteins by small inhibitors (BETis) is intriguing for many researchers. Among the BETis developed until now, JQ1, OTX015, and I-BET858 are non-covalent and selective inhibitors able to cross the blood–brain barrier (BBB) and produce molecular and behavioral responses in rodents [ 15 , 19 , 63 ].…”

Section: Structure and Functions Of Bet Proteinsmentioning

confidence: 99%

“…Particularly, pharmacological inhibition of BET proteins has been shown to normalize the behavioral symptoms in a wide range of disease models, including SUD [ 65 , 181 ] ( Table 2 ). In preclinical SUD studies, JQ1 was able to ameliorate the behavioral responses to different types of substances of abuse such cocaine, heroin, amphetamine, and nicotine in mice and rats [ 63 , 67 , 182 ].…”

Section: Involvement Of Bet Proteins In Neuropathological Conditionsmentioning

confidence: 99%

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Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

et al. 2023

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BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the development of BET inhibitors, interest in this protein family has risen for its relevance in brain development and function. For example, experimental evidence has shown that BET modulation affects neuronal activity and the expression of genes involved in learning and memory. In addition, BET inhibition strongly suppresses molecular pathways related to neuroinflammation. These observations suggest that BET modulation may play a critical role in the onset and during the development of diverse neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s disease, fragile X syndrome, and Rett syndrome. In this review article, we summarize the most recent evidence regarding the involvement of BET proteins in brain physiology and pathology, as well as their pharmacological potential as targets for therapeutic purposes.

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Section: Structure and Functions Of Bet Proteinsmentioning

confidence: 99%

Section: Involvement Of Bet Proteins In Neuropathological Conditionsmentioning

confidence: 99%

Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

et al. 2023

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“…The bromodomain inhibitor JQ1 (2 μl of 20 μmol/l) was injected before heroin SA, and it interrupted the read-out of functional group and decreased the heroin-seeking behaviors [ 88 ]. However, the systemic and intra-NAc administration of JQ1 did not affect the acquisition of morphine CPP in mice, while it also attenuated cocaine-seeking behaviors [ 93 ]. These different results reveal a complex interrelation between the regulators of epigenetic modification and carving behaviors of opioids, which indicate the significance of identifying the distinction between morphine and heroin in the potential treatment of opioids use disorders.…”

Section: Opioids and Histone Modificationsmentioning

confidence: 99%

Histone modifications in cocaine, methamphetamine and opioids

Cheng

Chen

et al. 2023

Heliyon

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“…Furthermore, cAMP/PKA signaling promoted the recruitment of Brd4 to dopamine-induced genes in striatal neurons, and the knockdown of Brd4 attenuated D1R-induced gene expression. The systemic and intra-accumbal inhibition of Brd4 with JQ1 attenuated the rewarding effects of cocaine or amphetamine-induced place preference [ 74 , 75 ]. Therefore, these findings indicate that PKA directly or indirectly phosphorylates CREB or Brd4 to promote the gene expression for synaptic plasticity regulated by dopamine.…”

Section: Pka and Pka Substratesmentioning

confidence: 99%

Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance

Zhang

Tsuboi²,

Funahashi³

et al. 2022

IJMS

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Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylation is critical for intracellular signaling pathways and physiological functions, which are regulated by neurotransmitters in the brain. Previous studies have demonstrated that dopamine stimulated the phosphorylation of intracellular substrates, such as receptors, ion channels, and transcription factors, to regulate neuronal excitability and synaptic plasticity through dopamine receptors. We also established a novel database called KANPHOS that provides information on phosphorylation signals downstream of monoamines identified by our kinase substrate screening methods, including dopamine, in addition to those reported in the literature. Recent advances in proteomics techniques have enabled us to clarify the mechanisms through which dopamine controls rewarding and aversive behaviors through signal pathways in the NAc. In this review, we discuss the intracellular phosphorylation signals regulated by dopamine in these two emotional behaviors.

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JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference

Cited by 9 publications

References 51 publications

Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

Histone modifications in cocaine, methamphetamine and opioids

Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance

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