Current building techniques in developing countries have become extremely critical. The net-zero energy concept has emerged as an essential strategy for minimising energy consumption and greenhouse gas emissions. However, its implementation, particularly in developing countries, remains a critical challenge. The purpose of this work is to assess the feasibility of achieving a net-zero energy building by combining energy-efficient design practices and renewable energy systems under the climatic conditions of the Republic of Congo. To achieve the stipulated objectives, DesignBuilder software was utilised for building modelling, energy load assessment and multiobjective optimisation of building energy efficiency measures, and the multicriteria energy optimisation was carried out using the HOMER tool. The optimisation results showed that the implementation of energy efficiency measures resulted in 39.15% energy savings, 43.45% thermal load savings and 55.68% discomfort hours reduction. Furthermore, the renewable energy system can provide 100% of the building’s energy load and a total savings of 3341.84 kgCO2eq/year. The system’s levelised cost of energy was estimated at 0.256 $/kWh, with a net present cost of $20,231, while the overall life cycle cost was calculated at 188.91 $/m2.