Juice fromFructus Rosae Roxburghiinormalizes blood lipids in mice with diet‐induced hyperlipidemia*^†

Abstract

generally characterized by high total cholesterol (TC) or triglyceride (TG), or low high-density lipoprotein (HDL). These lipoproteins play important role in regulating the blood lipid. Hypertriglyceridemia is a prevalent risk factor for CVD. Elevated TG levels are also important markers for several types of atherogenic lipoproteins (Malloy & Kane, 2001). LDL can transport the cholesterol on the surface of cells by LDL receptor and scavenger receptor, which can prevent excessive lipid accumulation (Goldstein & Brown, 2009; Hansson & Libby, 2006). Damaged LDL receptor would prompt the development of AS by accumulating intracellular lipid. LDL can be transformed into oxidized low-density lipoprotein (OX-LDL) under free