This article discusses religious coping behaviors in relation to Islamic spiritual care practices. Islamic spiritual care is an established practice, integrated in many European countries’ health and welfare services, and an emerging field of research. I have 17 years of experience as a Muslim chaplain in Danish hospitals and a prison, working with counseling, educating staff, and policymaking in the field of Muslim chaplaincy. In this article, I use psychological theory to analyze positive and negative religious coping, first demonstrating that spiritual care is a practice in Islam that is embedded in its theological and psychological (re)sources. Then, based on two case examples, I analyze negative religious coping among Muslims, which is a topic that has received little scholarly attention. The article contributes to the emerging field of Islamic practical theology and the interdisciplinary relationship between practical theology and psychology of religion.