Juniperus sibirica Burgsdorf. as a novel source of antioxidant and anti-inflammatory agents

Lesjak, Marija; Beara, Ivana; Orčić, Dejan; Anačkov, Goran; Balog, K; Francišković, M; Mimica–Dukić, Neda

doi:10.1016/j.foodchem.2010.07.006

Cited by 93 publications

(75 citation statements)

References 27 publications

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“…The strong antioxidant profiles of thyme, Juniper and clove oils have been proved in several studies. The results obtained from this study arein agreement with Lesjak, et al (2011), who reported that juniper extract has shown a significant DPPH scavenger activity, which was still notably lower than the synthetic antioxidant TBHQ. Gülçin, et al (2012) reported that the DPPH free radical scavenging activity of clove oil increased with an increasing concentration of clove oil.…”

Section: Antioxidative Activitysupporting

confidence: 92%

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Ramadan¹,

Ali²,

Ghanem³

et al. 2015

Grasas y Aceites

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SUMMARY:Inhibitors of tumor growth using extracts from aromatic plants are rapidly emerging as important new drug candidates for cancer therapy. The cytotoxicity and in vitro anticancer evaluation of the essential oils from thyme, juniper and clove has been assessed against five different human cancer cell lines (liver HepG2, breast MCF-7, prostate PC3, colon HCT116 and lung A549). A GC/MS analysis revealed that α-pinene, thymol and eugenol are the major components of Egyptian juniper, thyme and clove oils with concentrations of 31.19%, 79.15% and 82.71%, respectively. Strong antioxidant profiles of all the oils are revealed in vitro by DPPH and β-carotene bleaching assays. The results showed that clove oil was similarly potent to the reference drug, doxorubicin in prostate, colon and lung cell lines. Thyme oil was more effective than the doxorubicin in breast and lung cell lines while juniper oil was more effective than the doxorubicin in all the tested cancer cell lines except prostate cancer. In conclusion, the essential oils from Egyptian aromatic plants can be used as good candidates for novel therapeutic strategies for cancer as they possess significant anticancer activity. KEYWORDS:Anticancer; Antioxidant; Clove Juniper; Thyme RESUMEN: Aceites esenciales de plantas aromáticas egipcias como novedosos agentes anticancerígenos y antioxidantes en líneas celulares de cáncer humano. Los inhibidores de crecimiento de tumores usando extractos de plantas aromáticas están emergiendo con rapidez como nuevos e importantes medicamentos para el tratamiento del cáncer. La citotoxicidad y la acción anticancerígena in vitro de aceites esenciales de tomillo, enebro y clavo han sido evaluadas en cinco líneas celulares de cáncer humano (hígado HepG2, mama MCF-7, próstata PC3, colon HCT116 y pulmón A549). Los análisis de GC/MS mostraron que α-pineno, timol y eugenol son los principales componentes de los aceites egipcios de enebro, tomillo y clavo, con concentraciones de 31,19%, 79,15% y 82,71%, respectivamente. Se demuestra, mediante ensayos in vitro de blanqueo de DPPH y β-caroteno, el enérgico perfil antioxidante de todos los aceites. Los resultados mostraron que el aceite de clavo fue similar de potente al fármaco de referencia, doxorrubicina en las líneas celulares de próstata, colon y pulmón. El aceite de tomillo fue más efectivo que la doxorrubicina en las líneas celulares de mama y de pulmón, mientras que el aceite de enebro fue más eficaz que la doxorrubicina en todas las líneas celulares de cáncer ensayados, excepto en la de cáncer de próstata. En conclusión, los aceites esenciales de plantas aromáticas egipcias se pueden utilizar como buenos candidatos para nuevas estrategias terapéuticas para el cáncer al poseer una significativa actividad anticancerígena

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Section: Antioxidative Activitysupporting

confidence: 92%

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Ramadan¹,

Ali²,

Ghanem³

et al. 2015

Grasas y Aceites

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“…While the wood of common junipers growing in Archangelsk region is a substrate for only two species of wood-destroying fungi, pine and aspen can be damaged by 126 and 212 fungi species, respectively (Ershov and Ezhov 2009). The higher biotic stability of juniper trees can possibly be explained by the high content of extractives, which reaches 7.7 % (Lesjak et al 2011;Tunalier et al 2002;Uvarovskaya 2008;.…”

Section: Resultsmentioning

confidence: 99%

Juniper wood structure under the microscope

Боголицын

Zubov

Чухчин

et al. 2015

Planta

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The investigations confirm the physicochemical nature of the structure and self-assembly of wood substance and endorse its application in plant species. The characteristic morphological features, ultra-microstructure, and submolecular structure of coniferous wood matrix using junipers as the representative tree were investigated by scanning electron (SEM) and atomic-force microscopy (AFM). Novel results on the specific composition and cell wall structure features of the common juniper (Juniperus Communis L.) were obtained. These data confirm the possibility of considering the wood substance as a nanobiocomposite. The cellulose nanofibrils (20-50 nm) and globular-shaped lignin-carbohydrate structures (diameter of 5-60 nm) form the base of such a nanobiocomposite.

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“…Many biological activities have been reported for Juniperus sp. These include anti-inflammatory (Akkol, Guvenc, & Yesilada, 2009;Lesjak et al, 2011), diuretic, antiseptic (bacterial and fungal) (Cavaleiro, Pinto, Goncalves, & Salgueiro, 2006;Ennajar et al, 2009;Kour et al, 2008;Kusari, Lamshoft, & Spiteller, 2009;Miceli et al, 2009), anthelmintic (Kozan, Kupeli, & Yesilada, 2006), hypoglycaemic (Ju et al, 2008), hypotensive, abortifacient, antinociceptive (Akkol et al, 2009), antiviral (Sassi, Harzallah-Skhiri, Bourgougnon, & Aouni, 2008), anticancer (Kusari, Zuhlke, & Spiteller, 2010), antioxidant (Lesjak et al, 2011;Miceli et al, 2009;Orhan, Berkkan, Deliorman Orhan, Aslan, & Ergun, 2011;Ozturk, Tumen, Ugur, Aydogmus-Ozturk, & Topcu, 2011), anticholinesterase Ozturk et al, 2011) and analgesic properties (Moreno et al, 1998). They have also been found to be useful in the treatment of psoriasis (Koerfgen, 1964) and neurasthenic neurosis (Jonkov & Naidenov, 1974).…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective potential of phenolic-enriched fractions from four Juniperus species found in Portugal

et al. 2012

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Juniperus sibirica Burgsdorf. as a novel source of antioxidant and anti-inflammatory agents

Cited by 93 publications

References 27 publications

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Juniper wood structure under the microscope

The neuroprotective potential of phenolic-enriched fractions from four Juniperus species found in Portugal

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