Juquitiba-like Hantavirus from 2 Nonrelated Rodent Species, Uruguay

Delfraro, Adriana; Tomé, Lorena; D’Elı́a, Guillermo; Clara, Mario; Achaval, Federico; Jc, Russi; Rodonz, Arbiza

doi:10.3201/eid1409.080455

Cited by 37 publications

(36 citation statements)

References 12 publications

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“…We found highly similar hantaviruses (JUQ-like virus) occurring in three distantly related rodent species (O. nigripes, A. montensis and Oxy. judex) in the same location, in agreement with the identification of a JUQ-like virus in two different species in Uruguay: O. nigripes and Oxymycterus nasutus (Delfraro et al, 2008). This could be due to an incidental infection of A. montensis and Oxy.…”

supporting

confidence: 87%

“…2b). Taken together, our analyses of S and M segments demonstrated that the sequences of ARAUV isolates were very similar to JUQV isolates reported by others (Delfraro et al, 2008;Suzuki et al, 2004), and, due to historical precedence, we propose that ARAUV should be named JUQ-like virus.This study provides additional evidence that the scenario of hantavirus transmission in South America could be more complex than previously thought. We found highly similar hantaviruses (JUQ-like virus) occurring in three distantly related rodent species (O. nigripes, A. montensis and Oxy.…”

supporting

confidence: 85%

supporting

confidence: 85%

“…judex (10056), O. nigripes (10091) and A. montensis (10028) were all very similar (99 % sequence identity in pairwise comparisons), and phylogenies based on the partial S segment sequences (Fig. 1) indicated that they were all closely related to the other ARAUV sequences previously characterized from HPS patients (Raboni et al, 2005) and to some recently reported Juquitiba virus (JUQV)-like S segment sequences (Delfraro et al, 2008). This result shows the epidemiological link between ARAUV from HPS patients and ARAUV found in the rodents, which was missing in our previous report (Raboni et al, 2007).…”

mentioning

confidence: 60%

“…Although sporadic spillover between rodents species has been suggested (Childs et al, 1994;Delfraro et al, 2008;Sousa et al,. 2008), conclusive evidence that the studied viruses can establish productive infections in more than one rodent host species is still missing.…”

mentioning

confidence: 99%

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Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil)

Raboni

Hoffmann

Oliveira

et al. 2009

Journal of General Virology

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Over 1100 cases of hantavirus pulmonary syndrome (HPS) have occurred in Brazil since 1993, but little is known about Brazilian hantaviruses, and many of their rodent hosts remain unknown. The Araucaria hantavirus (ARAUV) was described recently from HPS patients from Paraná , in southern Brazil, but its host could not be identified. In this study, rodents were captured from regions with high HPS prevalence to address this issue. ARAUV RNA was detected in three distantly related rodent species: Oligoryzomys nigripes, Oxymycterus judex and Akodon montensis. Furthermore, a specimen of A. montensis was infected with a Jaborá -like virus, implying that A. montensis can be infected by at least two different hantaviruses. The presence of the same hantavirus strain in three different rodent species and the co-circulation of two different strains in the same rodent species highlight the potential for genomic reassortment, which could have an impact on hantavirus transmission dynamics in nature and on human epidemiology.Hantaviruses belong to the genus Hantavirus in the family Bunyaviridae and are found throughout most of the world. Similar to other members of the family, hantaviruses are enveloped viruses with an RNA genome comprised of three negative-sense, single-stranded segments. The large (L) RNA segment encodes an RNA-dependent RNA polymerase, the medium (M) segment encodes two envelope glycoproteins -Gn and Gc -processed from one precursor, and the small (S) segment encodes the nucleocapsid protein (N) (Plyusnin et al., 1996).Hantaviruses use small mammals as vectors, and in the wild, most of the different hantaviruses have been found to associate predominantly with a specific rodent species that acts as the host in a given geographical region (Plyusnin & Morzunov, 2001). Although sporadic spillover between rodents species has been suggested (Childs et al., 1994;Delfraro et al., 2008;Sousa et al.,. 2008), conclusive evidence that the studied viruses can establish productive infections in more than one rodent host species is still missing.Hantaviruses are transmitted to humans mainly through the inhalation of contaminated aerosols of rodent excreta (Lednicky, 2003;Schmaljohn & Patterson, 2001), but human-to-human transmission has also been described (Padula et al., 1998). These viruses are associated with two clinical syndromes, haemorrhagic fever with renal syndrome, described in Europe and Asia with a mortality rate of 1-15 %, and hantavirus pulmonary syndrome (HPS), described in the Americas with a mortality rate ranging from 40 to 60 % (Lundkvist & Niklasson, 1994;Johnson et al., 1999).Despite the increasing incidence of HPS in Brazil (Elkhoury, 2005), little is known about the genetic diversity of its causative agents, Brazilian hantaviruses (Table 1), and identification of their rodent hosts remains incomplete. The south-western region of the state of Paraná (southern Brazil, 26u 079 S 51u 319 W) is one of the most heavily affected areas of Brazil, with a high number of HPS cases: 168 cases have been reported ...

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supporting

confidence: 87%

supporting

confidence: 85%

supporting

confidence: 85%

mentioning

confidence: 60%

mentioning

confidence: 99%

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Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil)

Raboni

Hoffmann

Oliveira

et al. 2009

Journal of General Virology

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Hantavirus Disease

and

Raghuvanshi

2013

Emerging Epidemics

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Estimating pathogen‐spillover risk using host–ectoparasite interactions

Brennan,

Paulson,

Escobar

2024

Ecology and Evolution

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Pathogen spillover corresponds to the transmission of a pathogen or parasite from an original host species to a novel host species, preluding disease emergence. Understanding the interacting factors that lead to pathogen transmission in a zoonotic cycle could help identify novel hosts of pathogens and the patterns that lead to disease emergence. We hypothesize that ecological and biogeographic factors drive host encounters, infection susceptibility, and cross‐species spillover transmission. Using a rodent–ectoparasite system in the Neotropics, with shared ectoparasite associations as a proxy for ecological interaction between rodent species, we assessed relationships between rodents using geographic range, phylogenetic relatedness, and ectoparasite associations to determine the roles of generalist and specialist hosts in the transmission cycle of hantavirus. A total of 50 rodent species were ranked on their centrality in a network model based on ectoparasites sharing. Geographic proximity and phylogenetic relatedness were predictors for rodents to share ectoparasite species and were associated with shorter network path distance between rodents through shared ectoparasites. The rodent–ectoparasite network model successfully predicted independent data of seven known hantavirus hosts. The model predicted five novel rodent species as potential, unrecognized hantavirus hosts in South America. Findings suggest that ectoparasite data, geographic range, and phylogenetic relatedness of wildlife species could help predict novel hosts susceptible to infection and possible transmission of zoonotic pathogens. Hantavirus is a high‐consequence zoonotic pathogen with documented animal‐to‐animal, animal‐to‐human, and human‐to‐human transmission. Predictions of new rodent hosts can guide active epidemiological surveillance in specific areas and wildlife species to mitigate hantavirus spillover transmission risk from rodents to humans. This study supports the idea that ectoparasite relationships among rodents are a proxy of host species interactions and can inform transmission cycles of diverse pathogens circulating in wildlife disease systems, including wildlife viruses with epidemic potential, such as hantavirus.

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Juquitiba-like Hantavirus from 2 Nonrelated Rodent Species, Uruguay

Cited by 37 publications

References 12 publications

Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil)

Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil)

Hantavirus Disease

Estimating pathogen‐spillover risk using host–ectoparasite interactions

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