Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates UCP-1 and inflammation biomarkers induced by trans-fatty acids in the brown adipose tissue of offspring

Argentato, Perla Pizzi; Morais, Carina Almeida; Santamarina, Aline Boveto; César, Helena; Estadella, Débora; Rosso, Veridiana Vera de; Pisani, Luciana Pellegrini

doi:10.1016/j.yclnex.2016.12.002

Cited by 19 publications

(22 citation statements)

References 65 publications

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“…Accordingly, our results showed that the HFJ 0.25% group showed better biological activity and exhibited improvement in TAG and LDL-C levels than in the HFC and HFJ 0.5% groups, respectively. Thus, the superiority of the 0.25% dose of juçara could be confirmed by previous studies that used 0.5% and 2% of juçara pulp, which were associated with a hypercaloric diet and did not show any improvement in the lipid profile [ 20 , 35 ]. In addition, the HFJ 0.25% group showed effective reduction of serum FFA levels, which is a remarkable finding because high FFA levels are related to insulin resistance, cellular apoptosis, and proinflammatory cytokine production.…”

Section: Discussionmentioning

confidence: 57%

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

et al. 2018

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Obesity is associated with modern diets that are rich in saturated fatty acids. These dietary patterns are linked to low-grade proinflammatory mechanisms, such as the toll-like receptor 4/nuclear factor kappa-B (NF-κB) pathway rapidly activated through high-fat diets. Juçara is a berry rich in anthocyanins and unsaturated fatty acids, which prevents obesity and associated comorbidities. We evaluated the effect of different doses of freeze-dried juçara pulp on NF-κB pathway after the consumption of short-term high-fat diet. Male Wistar rats with ad libitum access to food and water were divided into four groups: Control diet (C), high-fat diet (HFC), high-fat diet with 0.25% juçara (HFJ 0.25%), and high-fat diet with 0.5% juçara (HFJ 0.5%). Energy intake and body weight gain were increased in HFC and HFJ 0.5% groups compared to C group. The hypothalamus weight reduced in the HFC group compared to C and HFJ 0.25% groups. Cytokines, MYD88, TRAF6, and pNF-κBp50 levels in the hypothalamus, serum triacylglycerol, LDL-cholesterol (LDL-C), and free fatty acid levels were improved in the HFJ 0.25% group. In summary, the HFJ 0.25% group had better protective effects than those in the HFJ 0.5%. Therefore, 0.25% juçara can be used to protect against central inflammation through the high-fat diet-induced NF-κB pathway.

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Section: Discussionmentioning

confidence: 57%

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

et al. 2018

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“…Considering juçaraʼs effect on the blood glucose, a study carried out by Oyama et al [18] had as a main result the improvement of glycemic response in mice fed with normocaloric, hypercaloric, or hyperlipidemic diet added with 0.5 % of juçara freezedried powder concentration. In the same way, the study by Argentato et al [55] was also effective in decreasing blood glucose after the addition of 0.5 % juçara freeze-dried powder concentration in the offspring during their maternal diet. Other studies reported a significant decrease in blood glucose after 2 % and 6 % of juçara freeze-dried extract in the diet of ApoE knockout mice compared to the control group [17].…”

Section: Authorsmentioning

confidence: 70%

“…The different animal models and concentrations of juçara in experimental studies make difficult to compare the investigations. Some investigations reported weight loss [16,55], decreased triglycerides [16,54,55], reduction of LDL-C [16,17], and decreased of TC [17,40,54], while other animal investigations have reported no effect on the lipid profile [14,18,40]. Despite the cardioprotective effect of berries being widely studied due to their content of bioactive compounds and ACNs, the effects of juçara intervention on lipid profile still seem inconclusive.…”

Section: Authorsmentioning

confidence: 99%

“…A study [55] supplemented juçara (0.5 %) in control diet and diet enriched with hydrogenated vegetable oil (with high content of trans fatty acids) on maternal diet during pregnancy and lactation in Wistar rats. The results showed that diets with a high content of trans fatty acids increased inflammatory markers (TNF-α and TNFRI), which was expected, whereas the groups receiving juçara increased the anti-inflammatory marker IL-10 concentration in the brown adipose tissue.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

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An Update on the Biological Activities of Euterpe edulis (Juçara)

et al. 2018

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The palm tree , known as juçara, produces spherical and purple fruits, similar to those of the and palm trees, from which the common name açaí originates. Juçara fruit has been gaining prominence in the scientific world for its interesting nutritional composition, which is rich in antioxidants, and for its sustainable production model. Recently, relevant biological activities have been associated with the juçara fruit, and its use in alimentation has become an important nutritional, environmental, and economic alternative. The aim of this review is to compile recent scientific data about the phytochemical characterization and biological activities of A review of the literature was conducted in two electronic databases, Medline and Science Direct. The eligibility criteria were as follows: phytochemicals characterize of the fruits and evaluate biological effects or with pulp, extract, juice, or product of juçara fruits. Investigations were excluded if they used other parts of the plant (seeds), did not assess biological activities, or have tested methodologies for compound extraction. From the identified reports, 25 articles were eligible for this study. The promotion of health benefits related to juçara fruits seems to have improved antioxidant activity benefits to lipid and glycemic profiles, and modulation of inflammatory status in experimental studies in animals.

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“…Increased offspring adiposity could be amplified if during lactation the maternal diet is high in fat (112) , demonstrating that maternal nutrition is an important regulator of obesity in the offspring. In animal models, there is evidence that maternal dietary fat programme BAT is strong (16,(104)(105)(106)(107)(108) . There is a limitation to human testing for ethical reasons, but the altered UCP-1 expression in offspring BAT from mothers whose diets were high in fat or had a low-quality fat source, for instance hydrogenated vegetable fats, during gestation and lactation could be a possible cause for the increased trend in childhood obesity.…”

Section: Future Research Directionsmentioning

confidence: 99%

Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue

et al. 2018

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Brown adipose tissue (BAT) has recently been given more attention for the part it plays in obesity. BAT can generate great amounts of heat through thermogenesis by the activation of uncoupling protein 1 (UCP-1), which can be regulated by many environmental factors such as diet. Moreover, the build-up of BAT relates to maternal nutritional changes during pregnancy and lactation. However, at present, there is a limited number of studies looking at maternal nutrition and BAT development, and it seems that the research trend in this field has been considerably declining since the 1980s. There is much to discover yet about the role of different fatty acids on the development of BAT and the activation of UCP-1 during the fetal and the postnatal periods of life. A better understanding of the impact of nutritional intervention on the epigenetic regulation of BAT could lead to new preventive care for metabolic diseases such as obesity. It is important to know in which circumstances lipids could programme BAT during pregnancy and lactation. The modification of maternal dietary fatty acids, amount and composition, during pregnancy and lactation might be a promising strategy for the prevention of obesity in the offspring and future generations.

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Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates UCP-1 and inflammation biomarkers induced by trans-fatty acids in the brown adipose tissue of offspring

Cited by 19 publications

References 65 publications

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

An Update on the Biological Activities of Euterpe edulis (Juçara)

Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue

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