Just the facts: rabies post-exposure prophylaxis

Ahmad, Omar; Moor-Smith, Maxwell; Hasselback, Paul

doi:10.1007/s43678-020-00018-2

Cited by 1 publication

(1 citation statement)

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“…8 , 9 Case reports documenting curative therapeutic vaccination for arteritis caused by P. insidiosum exist, 10 and postexposure prophylaxis with inactivated rabies vaccine has eliminated cases in the US among those treated. 11 , 12 However, CDC guidelines advocate against vaccination during COVID-19 illness despite the absence of prior studies assessing the effect of vaccination in the immediate peri-diagnostic period on clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

Is there an association between peri-diagnostic vaccination and clinical outcomes in COVID-19 patients?

Casazza,

Thakur,

Perl

et al. 2023

ASHE

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Background: Peri-diagnostic vaccination contemporaneous with SARS-CoV-2 infection might boost antiviral immunity and improve patient outcomes. We investigated, among previously unvaccinated patients, whether vaccination (with the Pfizer, Moderna, or J&J vaccines) during the week before or after a positive COVID-19 test was associated with altered 30-day patient outcomes. Methods: Using a deidentified longitudinal EHR repository, we selected all previously unvaccinated adults who initially tested positive for SARS-CoV-2 between December 11, 2020 (the date of vaccine emergency use approval) and December 19, 2021. We assessed whether vaccination between days –7 and +7 of a positive test affected outcomes. The primary measure was progression to a more severe disease outcome within 30 days of diagnosis using the following hierarchy: hospitalization, intensive care, or death. Results: Among 60,031 hospitalized patients, 543 (0.91%) were initially vaccinated at the time of diagnosis and 59,488 (99.09%) remained unvaccinated during the period of interest. Among 316,337 nonhospitalized patients, 2,844 (0.90%) were initially vaccinated and 313,493 (99.1%) remained unvaccinated. In both analyses, individuals receiving vaccines were older, more often located in the northeast, more commonly insured by Medicare, and more burdened by comorbidities. Among previously unvaccinated patients, there was no association between receiving an initial vaccine dose between days −7 and +7 of diagnosis and progression to more severe disease within 30 days compared to patients who did not receive vaccines. Conclusions: Immunization during acute SARS-CoV-2 infection does not appear associated with clinical progression during the acute infectious period.

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Section: Introductionmentioning

confidence: 99%