Juvenile bullous pemphigoid: the presentation and follow‐up of six cases

Gajić-Veljić, Mirjana; Nikolić, Miloš; Medenica, Ljiljana

doi:10.1111/j.1468-3083.2009.03264.x

Cited by 21 publications

(12 citation statements)

References 21 publications

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“…In early adolescence, we identified nine BP cases (six women, two men; in one, sex was not reported). [5][6][7][8][9][10][11][12] Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/ nicotinamide (1/9).…”

Section: Resultsmentioning

confidence: 99%

Bullous pemphigoid in adolescence

Patsatsi

Kyriakou

Werth

2018

Pediatric Dermatology

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Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10‐13 years), middle (14‐17), and late (18‐21). This review aimed to identify BP cases in adolescence and demonstrate their clinical features and course. Our literature search was performed in Medline with the terms “bullous pemphigoid in childhood and adolescence,” “childhood bullous pemphigoid,” “juvenile bullous pemphigoid,” and “autoimmune blistering and autoimmune bullous diseases in childhood.” The data extraction for late adolescence was limited by the fact that this age group is included in adult BP registries. We identified nine cases in early adolescence. Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/nicotinamide (1/9). Relapses were reported in 3 of 9 cases. We identified five cases occuring in middle adolescence. Mucosa were not affected. Treatment consisted of systemic prednisone (5/5), in combination with dapsone (3/5), azathioprine (2/5), doxycycline/nicotinamide (1/5), or mycophenolate mofetil (1/5). Relapses were reported in two of five cases. No case of BP in the late adolescence was included in the results, as only one case met the search criteria, and overlapped with pemphigus vulgaris. With only 14 cases found in our review, BP in adolescence appears even rarer than in earlier childhood. Despite its low prevalence, BP should be included in the differential diagnosis of autoimmune blistering diseases in adolescents.

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Section: Resultsmentioning

confidence: 99%

Bullous pemphigoid in adolescence

Patsatsi

Kyriakou

Werth

2018

Pediatric Dermatology

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“…7,8 Classically, the treatment of choice is performed with systemic corticosteroids at a dose of 1 to 2 mg/kg/day of prednisone, only enough to control the disease, and not to completely suppress the lesions. 3,4,6,7,9,11,15 Oral corticosteroids are generally well tolerated by children, and healing occurs after a few weeks or months of treatment. 7 Dapsone at 100 mg daily may be associated to systemic corticosteroids, with the aim to reduce the corticosteroid while maintaining the sulfone as described in our case.…”

Section: Discussionmentioning

confidence: 99%

“…4,5,10,11,13,15,18 As there is a possibility of spontaneous remission in childhood; treatment should not be aggressive or too toxic. 9 The occurrence of relapses is infrequent. 10 …”

Section: Discussionmentioning

confidence: 99%

Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood

Reis-Filho

Silva

Aguirre

et al. 2013

An. Bras. Dermatol.

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Bullous pemphigoid is an autoimmune subepidermal blistering dermatosis that is uncommon in childhood. We report a case of a female infant, 3 months old, which presented clinical and laboratory data for the confirmatory diagnosis of bullous pemphigoid. The authors used immunohistochemical staining for collagen type IV that allowed the differentiation of bullous pemphigoid from other subepidermal bullous diseases. Opportunely we review the clinical, immunological, therapeutic and prognostic features of this pathology in children.

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“…Bullous pemphigoid is an autoimmune blistering disease primarily affecting the elderly. The incidence of JBP is very low with <90 cases reported in the literature (1). In both adult and juvenile BP, lesions often begin as urticarial pruritic papules and plaques followed by the development of tense bullae on an erythematous base with prominent pruritus (2).…”

Section: Discussionmentioning

confidence: 99%