Juvenile hemangioma: A case report with an emphasis on its clinical phases (evolution and involution), and immunohistochemically distinctive physiologic differences

Bhagalia, Sanjay; Pardhe, Nilesh; Gupta, Manu; Jain, Manish

doi:10.4103/0973-029x.86705

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…However, the consistently lobular growth pattern of KHE is not a feature of KS, and HHV8 expression is absent in KHE. Infantile (juvenile) hemangioma may enter the differential diagnosis owing to a lobulated tumor border together with densely packed vascular nodules ( Figure 2 ), but these tumors spontaneously involute, are not associated with the Kasabach-Merritt phenomenon, and express GLUT-1 by immunohistochemistry ( 11 ).…”

Section: Intermediate (Locally Aggressive)mentioning

confidence: 99%

Vascular tumors of the mediastinum

Paral¹,

Krausz²

2020

Mediastinum

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Vascular tumors represent only a sliver of all tumors affecting the mediastinum, but they pose diagnostic challenges due to significant overlap among entities, ever-evolving classification schemes, and the exquisite rarity of some of the entities not only in the mediastinum but in pathology practice as a whole. Most of the vascular tumors are better known to the practice of soft tissue pathology, from which some of the knowledge of clinical behavior can be extrapolated. For example, the stratification of epithelioid hemangioendothelioma (EHE) into two biologically separate categories has effectively translated from the somatic soft tissues to the thorax. For other entities, the effective validation of soft tissue parameters is hindered by the small numbers of reported mediastinal cases. Many of the treatment modalities have also transferred over, with the key differences resting on the difficulty in achieving complete surgical resection for mediastinal tumors as opposed to those in the somatic soft tissues. Accordingly, systemic drug therapies have emerged as attractive options for some of the mediastinal vascular tumors, such as kaposiform hemangioendothelioma (KHE) and Kaposi sarcoma (KS). The categories presented herein mirror the classification scheme set forth by the 5th Edition WHO Classification of Soft Tissue and Bone Tumors. This review focuses on the biologically aggressive vascular neoplasms while limiting discussion of the benign entities to relevant comparisons in the differential diagnoses. While distinguishing among the benign entities has academic importance, in practice, the stakes are far higher for diagnosing the biologically aggressive tumors given their marked heterogeneity in clinical outcomes. Practical advice for problem areas in pathology will be reviewed alongside tumor pathobiology, including the latest in molecular diagnostics.

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Section: Intermediate (Locally Aggressive)mentioning

confidence: 99%

Vascular tumors of the mediastinum

Paral¹,

Krausz²

2020

Mediastinum

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“…Juvenile hemangioma may be located on any part of the body surface but is most common in the head and neck region in young children, with a girl to boy ratio of 1:3. [ 1 2 ] It may present in skin, subcutaneous tissue, mucous membranes of lips, mouth, or internal viscera. Intramuscular hemangiomas are rare, accounting for 0.8% of all benign vascular tumors.…”

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confidence: 99%