2004
DOI: 10.1017/s0033291704002843
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Juvenile- versus adult-onset depression: multiple differences imply different pathways

Abstract: The juvenile- versus adult-onset distinction appears to be important to heterogeneity in adult depression, implicating different individual and environmental factors during childhood, and different mechanisms in adult life.

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Cited by 58 publications
(65 citation statements)
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“…Recently, the study of the developmental pathways to adult psychopathology has become a fruitful method for delineating heterogeneity and examining mechanisms [Hill et al, 2004;Kendler et al, 2004;Vythilingam et al, 2002]. Ultimately, prospective studies are required, however retrospective approaches can yield valuable pointers over much shorter time spans, and in relation to targeted adult clinical disorders [Widom et al, 2004].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recently, the study of the developmental pathways to adult psychopathology has become a fruitful method for delineating heterogeneity and examining mechanisms [Hill et al, 2004;Kendler et al, 2004;Vythilingam et al, 2002]. Ultimately, prospective studies are required, however retrospective approaches can yield valuable pointers over much shorter time spans, and in relation to targeted adult clinical disorders [Widom et al, 2004].…”
Section: Introductionmentioning
confidence: 99%
“…For example, multiple environmental and genetic risk factors for depression have been identified, but these do not operate uniformly across subgroups defined by age of onset [Hill et al, 2004;Jaffee et al, 2002]. Identifying key differences within psychopathological groups represents a major challenge, conceptually and empirically [Angold and Pickles, 2003].…”
Section: Introductionmentioning
confidence: 99%
“…Hypotheses have been raised regarding differing etiological origin of adolescent onset depression compared to adult onset depression, since the former phenotype is more sensitive to environmental influences, and has a higher comorbidity with externalizing conditions (Hill et al, 2004;Jaffee et al, 2002;Laucht et al, 2009). Moreover, the extensive comorbidity has also given rise to questions about whether particular risk factors for specific disorders could actually be seen as general risk factors for a broader predisposition of mental health problems (Kessler et al, 2011).…”
Section: Course and Comorbiditymentioning
confidence: 99%
“…These do not establish that maternal depression is the key risk because it is associated with other psychiatric disorders and psychosocial risks. For example, many women with depression have a history of conduct problems and marked interpersonal difficulties in adult life (Jaffee et al 2002a;Hill et al 2004). Rates of conduct disorders in the children of mothers with depression and antisocial personality disorder are higher than among those with depression only (Kim-Cohen et al 2006a).…”
Section: Introductionmentioning
confidence: 99%