Juvenile idiopathic arthritis: An overview

Silva, S.H. Monika de

doi:10.4038/sljch.v44i2.7991

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 HLA B27 is a complex allele that is associated with JIA. 4 It has an immunological and inflammatory role in arthropathies, such as presentation of arthritogenic peptides, aberrant folding of surface heavy chains, misfolding, and enhanced intracellular microbial survival. 5 The pathogenesis of JIA may be influenced by an imbalance of pro-and anti-inflammatory cytokines, with TNF-α, IL-1, and IL-6 being the most important modulators.…”

Section: Introductionmentioning

confidence: 99%

The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients

Shahzad,

Tahir,

Shahzad

et al. 2024

Pak J Med Sci

View full text Add to dashboard Cite

Background & Objectives: JIA is a disease with different immunological characteristics and a complicated genetic foundation. HLA B27 is a risk factor for the development of JIA, and its impact on immunopathogenesis of the disease is also an area of interest. To determine whether HLA B27 and immune markers varied between JIA patients and healthy population. Methods: This comparative cross-sectional study was conducted at Immunology Department of University of Health sciences (UHS), Lahore from February 2018 till August 2021. A total of (71) JIA patients and (34) healthy controls were enrolled. B cells were enumerated by flowcytometry, ELISA was used for serum cytokines estimation and HLA B27 allele was detected by SPSS polymerase chain reaction. Results: The HLA B27 allele was significantly more in the control group than in the patient group, suggesting it is a protective allele to prevent JIA. Peripheral blood B cell counts and percentages were significantly lower in the HLA B27 positive group than in the HLA B27 negative group of control population. Serum cytokine levels were not significantly different between the HLA B27 positive and HLA B27 negative allele of the two study populations. Conclusion: In this study B cells are different between the two groups of control population however; serum cytokines are comparable between the study groups. Though, it was indicated that HLA B27 may be a preventive allele in the onset of JIA. doi: https://doi.org/10.12669/pjms.40.5.7915 How to cite this: Shahzad F, Tahir R, Shahzad F, Afzal N. The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.7915 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Introductionmentioning

confidence: 99%