Juvenile idiopathic arthritis and physical activity: Possible inflammatory and immune modulation and tracks for interventions in young populations

Rochette, Emmanuelle; Duché, Pascale; Merlin, Étienne

doi:10.1016/j.autrev.2015.04.007

Cited by 31 publications

(20 citation statements)

References 109 publications

(166 reference statements)

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“…This results in physical, mental, and metabolic disorders. Exercise training is beneficial for JIA children, and leads to improved muscle strength, range of motion, quality of life, and reduced joint stiffness, without affecting disease activity [21]. Therefore, preventing physical limitations and supporting exercise training is essential in JIA.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life among Swedish children with Juvenile Idiopathic Arthritis: parent–child discrepancies, gender differences and comparison with a European cohort

Lundberg

Eriksson

2017

Pediatr Rheumatol

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BackgroundThis study investigates gender differences in self-reports and between parent and child reports in Health-related Quality of Life (HRQOL), measured with disease-specific and generic instruments for chronic disease. Comparison of HRQOL results in this Juvenile Idiopathic Arthritis (JIA) sample to a European cohort of children with JIA and one of children with other health conditions are also made.MethodsFifty-three children with juvenile idiopathic arthritis (JIA), aged 8–18 years, and their parents completed the condition-specific DISABKIDS for JIA, and the DISABKIDS generic instrument for chronic conditions (DCGM-37) in a cross-sectional study. European reference data were used for comparison of child and parental reports.ResultsChild self-reports in DCGM-37 and DISABKIDS for JIA showed no gender differences. Parental and child reports of the child’s HRQOL differed only in DCGM-37; this was among girls who scored their independence (p = 0.03), physical limitation (p = 0.01), social exclusion (p = 0.03), emotions (p <0.01), and general transformed score (p <0.01) higher than did their parents. Our sample of children with JIA reported more physical limitation compared to samples of European children with JIA (p = 0.01), European children with chronic conditions (p < 0.01), and their parents (p = 0.01 and p < 0.01). The Swedish children reported more problem with understanding compared to the European JIA sample (p = 0.03). Swedish parents perceived their children’s independence significantly lower than did the European parents of JIA children (p < 0.01), as well as European parents of children with chronic conditions (p = 0.03). The Swedish parents also perceived their children to have significantly lower social inclusion (p < 0.05) and general transformed score (p = 0.04), in comparison to European parents of children with chronic conditions.ConclusionsParent–child differences in assessment of quality of life depend on the HRQOL instrument used, especially among girls. In comparison to European cohorts, our sample of children with JIA experienced more physical limitations and less understanding.

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Section: Discussionmentioning

confidence: 99%

Health-related quality of life among Swedish children with Juvenile Idiopathic Arthritis: parent–child discrepancies, gender differences and comparison with a European cohort

Lundberg

Eriksson

2017

Pediatr Rheumatol

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“…Also, physical activity may exacerbate underlying inflammatory processes. Through exercise, the secretion of various hormones, miRNAs, and peptides are influenced and it seems that muscle cell-derived IL-6 has a central role in the fine balancing of anti-inflammatory and pro-inflammatory cytokines [ 33 ].…”

Section: Classical Risk Factors Of Cardiovascular Diseases Are More Cmentioning

confidence: 99%

Mechanisms of vascular comorbidity in autoimmune diseases

Nagy

Nemeth²,

Buzás

2018

Current Opinion in Rheumatology

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Purpose of reviewPersuasive statistics support the clinical observation that because of cardiovascular comorbidities patients with inflammatory joint disease die significantly earlier despite anti-inflammatory therapy.Recent findingsThe reason for this earlier death is multifactorial and involves a combination of a complex genetic background, environmental influences, classical cardiovascular risk factors and the impact of anti-inflammatory therapy. We will describe the importance of several new mechanisms, especially the diverse intercellular communication routes including extracellular vesicles and microRNAs that support the development of cardiovascular comorbidities.SummaryThe aim of this review is to give an updated overview about the known risk factors in the development of cardiovascular comorbidities with the latest insights about their mechanism of action. Furthermore, the impact of newly identified risk factors and significance will be discussed.

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“…The autoimmune and inflammatory features of JIA appear complex. Children with JIA were found increased levels of activated CD4+ T-cells both in circulation and in the synovium [ 6 – 10 ]. In In oligo/polyarticular JIA, the activation of auto-reactive T-cells including Th1 and Th17 cells induced IFN-γ and IL-17 production, respectively, leading to the production of proinflammatory cytokines, chemokines and mediators such as IL-1, IL-6 and TNF-α [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the immunosuppressive function of regulatory T-cells (Tregs) with decreased anti-inflammatory cytokine IL-10 results in a loss of immune tolerance. Imbalance between auto-reactive Th1/Th17 and Tregs leads to the failure of T-cell tolerance to self-antigens, which contributes to synovial inflammation and subsequent joint damage [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and risk of juvenile idiopathic arthritis among children with allergic diseases: a nationwide population-based study

Lin

Shen

et al. 2016

Pediatr Rheumatol

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BackgroundEpidemiological research reveals that the incidence of allergic diseases and that of autoimmune diseases have been increasing in parallel, raising an interest in a potential link between the two disorders. However, the relationship between Th2-mediated allergic disease and Th1-mediated juvenile idiopathic arthritis (JIA) remains unclear. This population-based case-control study was aimed at investigating the development of childhood-onset allergic diseases and the subsequent risks of JIA.MethodsWe included 329 children with JIA diagnosed between 2000 and 2008, and 1316 age- and sex-matched controls. The odds ratios of developing JIA were calculated to determine an association with preexisting allergic diseases.ResultsThe incidence rate of JIA in Taiwan between 2000 and 2008 was 1.33 cases per 100,000 children/year according to the International League of Associations for Rheumatology (ILAR) criteria. The children with a single allergic disease had an increased risk of JIA, with adjusted odds ratios of developing JIA of 1.44 for allergic conjunctivitis (95 % confidence interval [CI], 1.07–1.95), 1.50 for allergic rhinitis (1.15–1.96), and 1.44 for asthma (1.00–2.10). The adjusted odds ratios increased with the number of concurrent allergic diseases from 1.50 (95 % CI, 1.12–2.01) for those with only one allergic disease to 1.72 (1.24–2.38) for those with at least two allergic diseases. The adjusted odds ratios of those with at least two allergic diseases increased to 1.84 (95 % CI, 1.19–2.86) for boys and 2.54 (1.42–4.54) for those older than 12 years. The children who made two or more medical visits for associated allergic diseases per year had an increased risk of JIA.ConclusionChildren with onset of allergic diseases were at increased risk of developing JIA. The increased risk was associated with the cumulative effect of concurrent allergic diseases and frequency of seeking medical care. Further study to investigate the role of Th2-mediated allergic diseases that contribute to the development of Th1-mediated JIA is warranted.

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Juvenile idiopathic arthritis and physical activity: Possible inflammatory and immune modulation and tracks for interventions in young populations

Cited by 31 publications

References 109 publications

Health-related quality of life among Swedish children with Juvenile Idiopathic Arthritis: parent–child discrepancies, gender differences and comparison with a European cohort

Health-related quality of life among Swedish children with Juvenile Idiopathic Arthritis: parent–child discrepancies, gender differences and comparison with a European cohort

Mechanisms of vascular comorbidity in autoimmune diseases

Epidemiology and risk of juvenile idiopathic arthritis among children with allergic diseases: a nationwide population-based study

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