Juvenile Idiopathic Arthritis Associated Uveitis

Carlsson, Emil; Beresford, Michael W.; Ramanan, Athimalaipet V; Dick, Andrew D; Hedrich, Christian M.

doi:10.3390/children8080646

Cited by 21 publications

(13 citation statements)

References 104 publications

(137 reference statements)

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“…Up to 60-80% of patients with oligoarticular JIA (oJIA) have ANA. Importantly, oJIA is linked to a significant incidence of uveitis, especially in patients who are ANA positive (ANA+) [25] .…”

Section: Discussionmentioning

confidence: 99%

Ocular Comorbidities in Juvenile Idiopathic Arthritis

Khalil,

Fouda,

Elbrashy

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Uveitis is the most widespread and serious extra-articular sign of juvenile idiopathic arthritis (JIA), which is the most prevalent rheumatic condition in children. Despite more effective treatment options, the prevalence of JIA illness remains high, making it so difficult to assess the disease's outcomes-especially if extra-articular symptoms are present. The maintenance of sight and effective care depend on early detection. Objective: The aim of the current study was to scan the eyes of kids with JIA in order to find any ocular symptoms as soon as possible and stop any problems that could result in blindness and vision loss. Patients and methods:The study included 97 children who have JIA of both sexes, their age was under 16. All patients were underwent to a clinical examination (general, musculoskeletal, and ophthalmic examination), as well as laboratory testing (ESR, RF, ANA, HLA-B27, and CRP). Results: Ocular complications of JIA were significant (P<0.05) in uveitis group compared with group without uveitis regarding synechia, macular edema, keratopathy, glaucoma, and mild visual impairment. Correlation showed that disease severity (JDAS 27) is independent risk factors affecting uveitis (r=0.7353, P=0.001). Other risk factors like disease duration, age, JIA subtype and anterior chamber cells as well as CRP and ESR, TLC, and ANA positivity were significantly correlated with uveitis (r=0.976 P=0. 032, r=0.728 P=0.014, r=0.932 P=0.042, r=0.963 P=0.026, r=0.854 P=0.045, r=0.768 P=0.036, r=0.697 P=0.057, r=0.719 P=0.019, consecutively). Conclusion: JIA-related uveitis might have disastrous consequences. Today, clinical and demographic criteria have been used largely to estimate the risk of developing uveitis in JIA patients. To uncover patient-specific risk variables, recent studies employed molecular proteomic and cellular phenotyping techniques.

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Section: Discussionmentioning

confidence: 99%

Ocular Comorbidities in Juvenile Idiopathic Arthritis

Khalil,

Fouda,

Elbrashy

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…The seven subtypes of Juvenile idiopathic arthritis (JIA) can be divided into JIA with low risk of uveitis (systemic arthritis and other unclassified arthritis), moderate risk (polyarthritis rheumatoid factor, RF, positive) and higher risk of uveitis (oligoarthritis, persistent or extended; polyarthritis RF negative; enthesitis related arthritis or ERA, juvenile psoriatic arthritis or JpSA) ( 73 , 74 ). Chronic silent anterior uveitis is usually non-granulomatous in oligo or polyarticular JIA, as is acute anterior uveitis of ERA.…”

Section: Non-infectious Uveitismentioning

confidence: 99%

Pediatric uveitis: Role of the pediatrician

et al. 2022

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The challenges of childhood uveitis lie in the varied spectrum of its clinical presentation, the often asymptomatic nature of disease, and the evolving nature of the phenotype alongside normal physiological development. These issues can lead to delayed diagnosis which can cause significant morbidity and severe visual impairment. The most common ocular complications include cataracts, band keratopathy, glaucoma, and macular oedema, and the various associated systemic disorders can also result in extra-ophthalmic morbidity. Pediatricians have an important role to play. Their awareness of the various presentations and etiologies of uveitis in children afford the opportunity of prompt diagnosis before complications arise. Juvenile Idiopathic Arthritis (JIA) is one of the most common associated disorders seen in childhood uveitis, but there is a need to recognize other causes. In this review, different causes of uveitis are explored, including infections, autoimmune and autoinflammatory disease. As treatment is often informed by etiology, pediatricians can ensure early ophthalmological referral for children with inflammatory disease at risk of uveitis and can support management decisions for children with uveitis and possible underling multi-system inflammatory disease, thus reducing the risk of the development of irreversible sequelae.

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“…Children with JIA seldom have the chorioretinal disease (except macular edema), and therefore, have an unremarkable FA and ICGA. [ 28 ] Patients with OTB and sarcoidosis can have significant retinal vasculitis and optic nerve head inflammation with hyperfluorescence on FA (not reported in BS), active choroiditis (does not occur in BS), and choroidal granulomas which present with hypofluorescence on both FA and ICGA (not reported in BS). [ 28 29 30 ] Concilio et al .…”

Section: Ophthalmic Manifestations Of Bsmentioning

confidence: 99%

“…[ 28 ] Patients with OTB and sarcoidosis can have significant retinal vasculitis and optic nerve head inflammation with hyperfluorescence on FA (not reported in BS), active choroiditis (does not occur in BS), and choroidal granulomas which present with hypofluorescence on both FA and ICGA (not reported in BS). [ 28 29 30 ] Concilio et al . [ 31 ] have recently reported the relevance of anterior segment OCT (AS-OCT) in an 8-year-old girl with bilateral anterior granulomatous uveitis with underlying BS.…”

Section: Ophthalmic Manifestations Of Bsmentioning

confidence: 99%